Research progress in cardiotoxicity of organophosphate esters

H Fang, L Yang, M Yan, Y Fan, J Zhu… - Frontiers in Pharmacology, 2023 - frontiersin.org
Organophosphate esters (OPEs) have been extensively utilized worldwide as a substitution
for brominated flame retardants. With an increased awareness of the need for environmental …

Signaling Pathways Governing Cardiomyocyte Differentiation

IK Mensah, H Gowher - Genes, 2024 - mdpi.com
Cardiomyocytes are the largest cell type that make up the heart and confer beating activity to
the heart. The proper differentiation of cardiomyocytes relies on the efficient transmission …

Novel and deleterious nucleotide variations in the HAND1 gene probably affect miRNA target sites and protein function in pediatric patients with congenital heart …

F Tabrizi, M Khatami, MM Heidari, J Bragança… - Molecular Biology …, 2024 - Springer
Background Congenital heart disease (CHD) is the most prevalent developmental defect
and principal cause of infant mortality and affects cardiac and large blood vessel structures …

Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

P Xie, X Jiang, J He, Q Pan, X Yang, Y Zheng, W Fan… - bioRxiv, 2024 - biorxiv.org
The mammalian heart is formed from multiple mesoderm-derived cell lineages. However, it
remains largely unknown when and how the specification of mesoderm towards cardiac …

Advances and Prospects in Understanding Vertebrate Cardiac Conduction System, Pacemaker Cell, and Cardiac Muscle Development: Toward Novel Biological …

RO Bello, S Frew, Y Siddiqui, R Minhas - Muscles, 2023 - mdpi.com
The heart is composed of muscle cells called cardiomyocytes, including a specialized
population named pacemaker cells that form the cardiac conduction system (CCS), which is …

[PDF][PDF] (Epi) genetic control of transcription factor binding and activity across the genome

HK Neikes - 2024 - repository.ubn.ru.nl
The Peyer's patches (PP) are focal points within the small intestine, constituted by an
organized lymphoid follicle and an overlying follicle-associated epithelium (FAE)(Corr et al …

Differential ERK activity shapes the epiblast methylome influencing cell-context response to germ-layer differentiation signals.

E Ferretti, N Menezes, K Peterson, X Guo, V Castiglioni… - 2023 - researchsquare.com
Stem cells hold promise in regenerative medicine as they have the potency to differentiate
into a variety of specialized cell types. However, mechanisms underlying stem cell plasticity …

The development of specialised cardiac muscle cells within a vertebrate heart requires a specialised regulatory network

S Frew, Y Siddiqui, R Minhas - 2023 - preprints.org
Heart is composed of muscle cells called cardiomyocytes, including a specialized
population, named pacemaker cells, that form the Cardiac Conduction System (CCS) …

Transcriptional regulation of cardiac development and disease

N Wagner, KD Wagner - International Journal of Molecular Sciences, 2022 - mdpi.com
The heart, which is the first organ to develop in the embryo, is indispensable for vital
functions throughout life. Cardiovascular diseases are the leading cause of mortality …

Yap and Taz are Required for Neural Crest-Derived Cardiovascular Development

S Erhardt - 2022 - digitalcommons.library.tmc.edu
Congenital heart defects (CHDs) are the most common human birth defect, occurring in~
1/100 newborns, and are a leading cause of early infant death. Cardiac neural crest cells …