Natural products and synthetic small molecules can be used to perturb, dissect and
manipulate biological processes, thereby providing the basis for drug development. Over the …

The development of synthetic, metal-based catalysts to perform intracellular bioorthogonal
reactions represents a relatively new and important area of research that combines …

Metal N‐heterocyclic carbene (NHC) complexes are a promising class of anti‐cancer agents
displaying potent in vitro and in vivo activities. Taking a multi‐faceted approach employing …

Identification of the molecular target (s) of anticancer metal complexes is a formidable
challenge since most of them are unstable toward ligand exchange reaction (s) or biological …

Detection of biomarkers in biosystems plays a key role in advanced biodiagnostics for
research and clinical use. Design of new analytical platforms is challenging and in demand …

The platinum-based anticancer agents cisplatin, carboplatin, and oxaliplatin represent a
spectacular translational science achievement. The basic research observations that led to …

Known as highly efficient metallodrugs that have been clinically used to treat various types
of cancers, cisplatin and its analogues have attracted and inspired extensive interest in the …

Click chemistry is fundamentally important to medicinal chemistry and chemical biology. It
represents a powerful and versatile tool, which can be exploited to develop novel Pt-based …

Cancer continues to be responsible for the deaths of more than 9 million people worldwide
each year. Current treatment options are diverse, but low success rates, particularly for those …

Neither palladium nor platinum is an endogenous biological metal. Imaging palladium in
biological samples, however, is becoming increasingly important because bioorthogonal …