Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …

Background Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with a poor
prognosis. The underlying functions and mechanisms of circular RNA and SUMOylation in …

Background Helicobacter pylori (H. pylori) infection causes aberrant DNA methylation and
contributes to the risk of gastric cancer (GC). Guanine nucleotide-binding protein subunit …

The liver is one of the few organs that retain the capability to regenerate in adult mammals.
This regeneration process is mainly facilitated by the dynamic behavior of hepatocytes …

Despite the robust regenerative capacity of the liver, prolonged and severe liver damage
impairs liver regeneration, leading to liver failure. Since the liver co-opts the differentiation of …

Conclusions: Hepatocyte-to-BEC conversion occurs through transdifferentiation
independently of proliferation, and Notch and Yap signaling control the process in parallel …

Extrahepatic cholangiocarcinoma (eCCA) contains perihilar cholangiocarcinoma and distal
cholangiocarcinoma both of which can arise at any point of the biliary tree and originate from …

The intestine and liver share a unique regenerative property that sets them apart from other
mammalian visceral organs. The intestinal epithelium exhibits rapid renewal, making it one …