Role of adipose tissue macrophages in obesity-related disorders

S Chakarov, C Blériot, F Ginhoux - Journal of Experimental Medicine, 2022 - rupress.org
The obesity epidemic has led researchers and clinicians to reconsider the etiology of this
disease and precisely decipher its molecular mechanisms. The excessive accumulation of …

Overweight and obesity in pregnancy: their impact on epigenetics

C Reichetzeder - European journal of clinical nutrition, 2021 - nature.com
Over the last few decades, the prevalence of obesity has risen to epidemic proportions
worldwide. Consequently, the number of obesity in pregnancy has risen drastically …

Maternal obesity, diabetes during pregnancy and epigenetic mechanisms that influence the developmental origins of cardiometabolic disease in the offspring

P Agarwal, TS Morriseau, SM Kereliuk… - Critical reviews in …, 2018 - Taylor & Francis
Since 1980, global obesity has doubled, and the incidence of cardiometabolic diseases
such as type 2 diabetes and heart disease is also increasing. While genetic susceptibility …

Resveratrol supplementation of high‐fat diet‐fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring

T Zou, D Chen, Q Yang, B Wang, MJ Zhu… - The Journal of …, 2017 - Wiley Online Library
Key points Maternal high‐fat diet impairs brown adipocyte function and correlates with
obesity in offspring. Maternal resveratrol administration recovers metabolic activity of …

The beige adipocyte as a therapy for metabolic diseases

F Lizcano - International journal of molecular sciences, 2019 - mdpi.com
Adipose tissue is traditionally categorized into white and brown relating to their function and
morphology. The classical white adipose tissue builds up energy in the form of triglycerides …

Mechanisms in endocrinology: skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes: a causal mechanism or an innocent bystander?

C Brøns, LG Grunnet - European Journal of Endocrinology, 2017 - academic.oup.com
Dysfunctional adipose tissue is associated with an increased risk of developing type 2
diabetes (T2D). One characteristic of a dysfunctional adipose tissue is the reduced …

Dietary alpha‐ketoglutarate promotes beige adipogenesis and prevents obesity in middle‐aged mice

Q Tian, J Zhao, Q Yang, B Wang, JM Deavila… - Aging …, 2020 - Wiley Online Library
Aging usually involves the progressive development of certain illnesses, including diabetes
and obesity. Due to incapacity to form new white adipocytes, adipose expansion in aged …

The role of gut microbiota in the effects of maternal obesity during pregnancy on offspring metabolism

L Zhou, X Xiao - Bioscience reports, 2018 - portlandpress.com
Obesity is considered a global epidemic. Specifically, obesity during pregnancy programs
an increased risk of the offspring developing metabolic disorders in addition to the adverse …

Maternal obesity and programming of metabolic syndrome in the offspring: searching for mechanisms in the adipocyte progenitor pool

TB Scheidl, AL Brightwell, SH Easson, JA Thompson - BMC medicine, 2023 - Springer
Background It is now understood that it is the quality rather than the absolute amount of
adipose tissue that confers risk for obesity-associated disease. Adipose-derived stem cells …

Epigenetics: linking early postnatal nutrition to obesity programming?

L Marousez, J Lesage, D Eberlé - Nutrients, 2019 - mdpi.com
Despite constant research and public policy efforts, the obesity epidemic continues to be a
major public health threat, and new approaches are urgently needed. It has been shown that …