New tetrahydropyrimidine-1, 2, 3-triazole clubbed compounds: Antitubercular activity and Thymidine Monophosphate Kinase (TMPKmt) inhibition
Two series of new tetrahydropyrimidine (THPM)-1, 2, 3-triazole clubbed compounds were
designed, synthesized and screened for their antitubercular (anti-TB) activity against M …
designed, synthesized and screened for their antitubercular (anti-TB) activity against M …
Challenging the Biginelli scaffold to surpass the first line antitubercular drugs: Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) inhibition …
MS El-Shoukrofy, A Atta, S Fahmy… - Journal of Enzyme …, 2024 - Taylor & Francis
New Biginelli adducts were rationalised, via the introduction of selected anti-tubercular (TB)
pharmacophores into the dihydropyrimidine (DHPM) ring of deoxythymidine …
pharmacophores into the dihydropyrimidine (DHPM) ring of deoxythymidine …
Synthesis, antitubercular evaluation, and molecular docking studies of hybrid pyridinium salts derived from isoniazid
GV Bhavani, SK Kondapuram… - Drug Development …, 2023 - Wiley Online Library
In the quest to develop potent inhibitors for Mycobacterium tuberculosis, novel isoniazid‐
based pyridinium salts were designed, synthesized, and tested for their antimycobacterial …
based pyridinium salts were designed, synthesized, and tested for their antimycobacterial …
Design, synthesis and biological evaluation of novel pyrido-[2, 3-d]-pyrimidin-2-amine analogues as antimycobacterial agents
BVS Kumar, YM Khetmalis, KS Chaitanya… - Journal of Molecular …, 2024 - Elsevier
Abstract Thirty-eight novel Pyrido-[2, 3-d]-pyrimidin-2-amine derivatives (P1-P38) were
designed, synthesized, and their structures confirmed using analytical techniques viz., 1 H …
designed, synthesized, and their structures confirmed using analytical techniques viz., 1 H …
Synthesis of Pyrido [2, 3-d] pyrimidines Catalyzed by 2, 3-Dichloro-5, 6-dicyano-1, 4-benzoquinone (DDQ)/tert-Butyl Nitrite (TBN)/O2
D Cheng, H Xia, H Gu, Y Wang, JH Li, X Xu - Synthesis, 2023 - thieme-connect.com
Catalyzed by 2, 3-dichloro-5, 6-dicyano-1, 4-benzoquinone (DDQ)/tert-butyl nitrite (TBN)/O
2, an efficient tandem oxidative reaction of uracils/thiouracil with 1, 3-diarylpropenes is …
2, an efficient tandem oxidative reaction of uracils/thiouracil with 1, 3-diarylpropenes is …
Novel pyrimidine–Imines against tuberculosis: Rationale, in vitro, in silico studies and mechanistic insights
Two series of novel multifunctional pyrimidine–imine hybrids were synthesized and
evaluated for their antitubercular and antimicrobial properties. A novel synthetic …
evaluated for their antitubercular and antimicrobial properties. A novel synthetic …
ATIVIDADE CONTRA O GÊNERO LEISHMANIA POR MEIO DO DESENVOLVIMENTO DE COMPOSTOS À BASE DE INDOL
JWR de Lucena, DS de Oliveira… - Revista …, 2023 - editoraintegrar.com.br
Resumo INTRODUÇÃO: As leishmanioses têm um impacto significativo na saúde pública e
os tratamentos existentes apresentam graves efeitos adversos e há inúmeros relatos de …
os tratamentos existentes apresentam graves efeitos adversos e há inúmeros relatos de …
[引用][C] ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ ОБРАЗОВАТЕЛЬНОЕ УЧРЕЖДЕНИЕ ВЫСШЕГО ОБРАЗОВАНИЯ «ЛУГАНСКИЙ …
ИВ ДЯЧЕНКО, АИХ ГЕТЕРОЦИКЛОВ