Nitric oxide signaling in health and disease

JO Lundberg, E Weitzberg - Cell, 2022 - cell.com
The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics

E Pajarillo, A Rizor, J Lee, M Aschner, E Lee - Neuropharmacology, 2019 - Elsevier
Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …

Oxidative stress‐related mechanisms in schizophrenia pathogenesis and new treatment perspectives

EA Ermakov, EM Dmitrieva… - Oxidative Medicine …, 2021 - Wiley Online Library
Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …

The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

Y Chen, C Qin, J Huang, X Tang, C Liu… - Cell …, 2020 - Wiley Online Library
Central nervous system (CNS) maintains a high level of metabolism, which leads to the
generation of large amounts of free radicals, and it is also one of the most vulnerable organs …

Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial …

P Toth, S Tarantini, A Csiszar… - American Journal of …, 2017 - journals.physiology.org
Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

Hsp70 in redox homeostasis

H Zhang, W Gong, S Wu, S Perrett - Cells, 2022 - mdpi.com
Cellular redox homeostasis is precisely balanced by generation and elimination of reactive
oxygen species (ROS). ROS are not only capable of causing oxidation of proteins, lipids and …

Protein S-nitrosylation: determinants of specificity and enzymatic regulation of S-nitrosothiol-based signaling

CT Stomberski, DT Hess, JS Stamler - Antioxidants & redox …, 2019 - liebertpub.com
Significance: Protein S-nitrosylation, the oxidative modification of cysteine by nitric oxide
(NO) to form protein S-nitrosothiols (SNOs), mediates redox-based signaling that conveys, in …

Chemical methods for mapping cysteine oxidation

LJ Alcock, MV Perkins, JM Chalker - Chemical Society Reviews, 2018 - pubs.rsc.org
Cysteine residues in proteins are subject to diverse redox chemistry. Oxidation of cysteine to
S-nitrosocysteine, cysteine sulfenic and sulfinic acids, disulfides and persulfides are a few …

Branched-chain amino acids and brain metabolism

JE Sperringer, A Addington, SM Hutson - Neurochemical research, 2017 - Springer
This review aims to provide a historical reference of branched-chain amino acid (BCAA)
metabolism and provide a link between peripheral and central nervous system (CNS) …

Astrocytic oxidative/nitrosative stress contributes to Parkinson's disease pathogenesis: the dual role of reactive astrocytes

A Rizor, E Pajarillo, J Johnson, M Aschner, E Lee - Antioxidants, 2019 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide; it is characterized by dopaminergic neurodegeneration in the substantia nigra …