While the use of ergot alkaloids in folk medicine has been practiced for millennia, systematic
investigations on their therapeutic potential began about 100 years ago. Subsequently …

Unprecedented enantioselective intramolecular Heck carbonylation reactions of
arenediazonium salts were enabled by a chiral N, N ligand. This reaction constitutes the first …

To illustrate the synthetic significance of C–C activation methods, here we describe an
efficient strategy for the enantioselective total syntheses of (−)-cycloclavine and (−)-5-epi …

The Wittig reaction is the chemical reaction of an aldehyde or ketone with a triphenyl
phosphonium ylide (the Wittig reagent) to afford an alkene and triphenylphosphine oxide …

A unified enantioselective synthesis and the biological evaluation of all rugulovasine
stereoisomers are reported. The syntheses are centered on the divergent and …

A base-assisted dearomative [2+ 1] spiroannulation of p/o-bromophenols with activated
olefins (methylenemalonates) to construct various cyclopropyl spirocyclohexadienone …

Sequential reactions are important for the direct and convenient synthesis of complex
molecules with multiple chiral centers. Here, we report an enantioselective sequential …

The first total synthesis of natural (+)-cycloclavine uses a catalytic asymmetric
cyclopropanation of allene, a regiospecific Pd-catalyzed enone formation, and two …

Fused indole alkaloids are an important part of naturally occurring indole alkaloids and have
attracted considerable interests from synthetic chemists because of their unique structures …

Developing effective carbon-carbon bond forming strategies is one of the central topics for
organic chemistry, boosting the development of synthetic methods towards complex …