The nicotinic acetylcholine receptor has served, since its biochemical identification in the
1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the …

Nicotinic acetylcholine, serotonin type 3, γ-amminobutyric acid type A, and glycine receptors
are major players of human neuronal communication. They belong to the family of …

A critical event in the history of biological chemistry was the chemical identification of the first
neurotransmitter receptor, the nicotinic acetylcholine receptor. Disciplines as diverse as …

Orthologs of the pentameric receptor channels that mediate fast synaptic transmission in the
central and peripheral nervous systems have been found in several bacterial species and in …

Membrane ion channels are the fundamental electrical components in the nervous system.
Recent developments in X-ray crystallography and cryo-EM microscopy have revealed what …

It is now well established that antibodies have numerous potential benefits when developed
as therapeutics. Here, we evaluate the technical challenges of raising antibodies to …

1. INTRODUCTION Ligand-gated ion channels (LGICs) mediate intercellular communication
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …

Pentameric ligand-gated ion channels (pLGICs) play a central role in intercellular
communications in the nervous system by converting the binding of a chemical messenger …

This review outlines recent insights into ligand recognition, channel gating and ion
permeation for the family of pentameric ligand-gated ion channels (pLGICs). These …

Pentameric ligand-gated ion channels (pLGICs) are ubiquitous neurotransmitter receptors in
Bilateria, with a small number of known prokaryotic homologues. Here we describe a new …