Oligodendrocyte dysfunction has been implicated in the pathogenesis of neurodegenerative
diseases, so understanding oligodendrocyte activation states would shed light on disease …

Loss of myelin and altered oligodendrocyte distribution in the cerebral cortex are commonly
observed both in postsurgical tissue derived from different focal epilepsies (such as focal …

Oligodendrocytes are highly specialized glial cells, responsible for producing myelin in the
central nervous system (CNS). The multi-stage process of oligodendrocyte development is …

In demyelinating diseases, such as multiple sclerosis, primary loss of myelin and
subsequent neuronal degeneration throughout the CNS impair patient functionality. While …

Tuberous sclerosis complex (TSC) is a monogenetic disease that arises due to mutations in
either the TSC1 or TSC2 gene and affects multiple organ systems. One of the hallmark …

Tuberous sclerosis complex (TSC) represents the prototypic monogenic disorder of the
mammalian target of rapamycin (mTOR) pathway dysregulation. It provides the rational …

Mutations in DEP domain containing 5 (DEPDC5) are increasingly appreciated as one of the
most common causes of inherited focal epilepsy. Epilepsies due to DEPDC5 mutations are …

In the CNS, oligodendrocyte progenitor cells (OPCs) differentiate into mature
oligodendrocytes to generate myelin, an essential component for normal nervous system …

Conduction of action potentials along myelinated axons is affected by their structural
features, such as the axonal g-ratio, the ratio between the inner and outer diameters of the …

Oligodendrocyte precursor cells (OPCs) differentiate and mature into oligodendrocytes,
which produce myelin in the central nervous system. Prior studies have shown that the …