Heat shock proteins (HSPs) are molecular chaperones that assist diverse cellular activities
including protein folding, intracellular transportation, assembly or disassembly of protein …

Small-molecule inhibitors for the 90-kDa heat shock protein (HSP90) have been extensively
exploited in preclinical studies for the therapeutic interventions of human diseases …

RNA contains more than 170 types of chemical modifications, and these modified
nucleosides are recognized, installed and removed by their reader, writer, and eraser (RWE) …

Epitranscriptomic reader, writer, and eraser (RWE) proteins recognize, install, and remove
modified nucleosides in RNA, which are known to play crucial roles in RNA processing …

Lymph node metastasis indicates a poor prognosis in colorectal cancer. To better
understand the underlying mechanisms of lymph node metastasis, we analyzed …

Prostate cancer is the most common type of cancer in men, and kinases are heavily pursued
as drug targets for anticancer therapy. In this study, we applied our recently reported parallel …

Kinases are among the most important families of enzymes involved in cell signaling. In this
study, we employed a recently developed parallel-reaction monitoring (PRM)-based …

As optimum temperature is essential for all living organisms, heat shock represents a
challenging problem for their survival. Therefore, cellular response to heat shock is among …

Kinases are crucial components in numerous cell signaling pathways. Aberrant expression
and activation of protein kinases are known to be accompanied by many types of cancer …

Melanoma is the deadliest skin tumor and is prone to distant metastases. The incidence of
melanoma has increased rapidly in the past few decades, and current trends indicate that …