Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

The cuprizone mouse model allows the investigation of the complex molecular mechanisms
behind nonautoimmune-mediated demyelination and spontaneous remyelination. While it is …

Most chronic diseases—such as cancer, cardiovascular disease (CVD), Alzheimer disease,
Parkinson disease, arthritis, diabetes and obesity—are becoming leading causes of …

Cyclooxygenases (COXs) oxidize arachidonic acid to prostaglandin (PG) G 2 and H 2
followed by PG synthases that generates PGs and thromboxane (TX) A 2. COXs are divided …

T2*-weighted gradient-echo MRI images at high field (≥ 7T) have shown rich image
contrast within and between brain regions. The source for these contrast variations has been …

Infiltration of macrophages plays a critical role in the connection between inflammation and
cancer invasion; however, the molecular mechanism that enables this crosstalk remains …

Inflammation is a major risk factor for neonatal white matter injury (NWMI), which is
associated with later development of cerebral palsy. Although recent studies have …

Cyclooxygenase-1 and-2 (COX1 and COX2) derived endogenous ligand prostaglandin-E2
(PGE2) triggers several physiological and pathological conditions. It mediates signaling …

Alzheimer's disease (AD) is characterized by the loss of neurogenesis and excessive
induction of apoptosis. The induction of neurogenesis and inhibition of apoptosis may be a …

Oligodendrogenesis and oligodendrocyte precursor maturation are essential processes
during the course of central nervous system development, and lead to the myelination of …