In the normal central nervous system, endothelin-1 (ET-1) is found in some types of neurons,
epithelial cells of the choroid plexus, and endothelial cells of microvessels, but it is usually …

Stroke is one of the most important causes of mortality and morbidity in the world. Prevention
and effective treatment of stroke is of the utmost importance. Cerebral ischemia causes …

Here, we have investigated the effect of metformin pretreatment in the rat models of global
cerebral ischemia. Cerebral ischemia which leads to brain dysfunction is one of the main …

Stroke is a life-threatening disease characterized by rapidly developing clinical signs of focal
or global disturbance of cerebral function due to cerebral ischemia. A number of flavonoids …

Edaravone, an antioxidant protective agent, has anti-cerebral ischemic reperfusion injury
(CIRI) effects, but its anti-CIRI mechanism is unclear. The aim of this study is to investigate …

Accumulation of neutrophils in brain after transient focal stroke remains controversial with
some studies showing neutrophils to be deleterious, whereas others suggest neutrophils do …

Stroke is a major cause of mortality and disability. The management with thrombolytic
therapy has to be initiated within 3–4h and is associated with limitations like increased risk …

The present study was designed to explore the mechanism of hesperidin action via the nitric
oxide pathway in the protection against ischemic reperfusion cerebral injury-induced …

Oxidative stress, inflammation and apoptotic neuronal cell death are cardinal mechanisms
involved in the cascade of acute ischemic stroke. Lercanidipine apart from calcium channel …

ETHNOPHARMACOLOGICAL RELEVANCE: Arogyavardhini vati, an Ayurvedic polyherbal
formulation has been used for liver and skin disorders in the Ayurvedic system of medicine …