Multi-omics integration and epilepsy: towards a better understanding of biological mechanisms

D Chong, NC Jones, RB Schittenhelm… - Progress in …, 2023 - Elsevier
The epilepsies are a group of complex neurological disorders characterised by recurrent
seizures. Approximately 30% of patients fail to respond to anti-seizure medications, despite …

Recent developments in diagnosis of epilepsy: scope of MicroRNA and technological advancements

R Bandopadhyay, T Singh, MM Ghoneim, S Alshehri… - Biology, 2021 - mdpi.com
Simple Summary Through epilepsy is one of the leading causes of poor mental health,
increased school dropout, and socioeconomic burden, yet the diagnosis remains a …

Integration of the CA2 region in the hippocampal network during epileptogenesis

A Kilias, S Tulke, N Barheier, P Ruther… - …, 2023 - Wiley Online Library
The CA2 pyramidal cells are mostly resistant to cell death in mesial temporal lobe epilepsy
(MTLE) with hippocampal sclerosis, but they are aberrantly integrated into the epileptic …

Aberrant hippocampal mossy fibers in temporal lobe epilepsy target excitatory and inhibitory neurons

B Puhahn‐Schmeiser, K Leicht, F Gessler… - …, 2021 - Wiley Online Library
Objective The pathoanatomical correlate of temporal lobe epilepsy is hippocampal sclerosis,
characterized by selective neuronal death of mossy cells in the hilus and of pyramidal cells …

Theory and computation of nuclear shielding

T Kupka - 2020 - books.rsc.org
A review of the literature published from January to December 2019 on theoretical aspects
of nuclear magnetic shielding is presented. It covers both non-relativistic and relativistic …

Innovative minimally invasive options to treat drug-resistant epilepsies

L Samalens, C Courivaud, JF Adam, EL Barbier… - Revue …, 2024 - Elsevier
Despite the regular discovery of new molecules, one-third of epileptic patients are resistant
to antiepileptic drugs. Only a few can benefit from resective surgery, the current gold …

High‐resolution magic angle spinning NMR for intact biological specimen analysis: Initial discovery, recent developments, and future directions

LL Cheng - NMR in Biomedicine, 2023 - Wiley Online Library
High‐resolution magic angle spinning (HRMAS) NMR, an approach for intact biological
material analysis discovered more than 25 years ago, has been advanced by many …

[HTML][HTML] Focal corticarl dysplasia in epilepsy is associated with GABA increase

T Gong, Y Liu, Y Chen, L Lin, Y Lin, G Wang - NeuroImage: Clinical, 2021 - Elsevier
Purpose Focal cortical dysplasia (FCD) is a major cause of drug-resistant epilepsy; however
the underlying epileptogenic mechanisms of FCD metabolism in epilepsy patients remain …

Neurovascular multiparametric MRI defines epileptogenic and seizure propagation regions in experimental mesiotemporal lobe epilepsy

F Boux, F Forbes, N Collomb, E Zub, L Mazière… - …, 2021 - Wiley Online Library
Objective Improving the identification of the epileptogenic zone and associated seizure‐
spreading regions represents a significant challenge. Innovative brain‐imaging modalities …

Clinical Correlation of Altered Molecular Signatures in Epileptic Human Hippocampus and Amygdala

SM Modarres Mousavi, F Alipour, F Noorbakhsh… - Molecular …, 2024 - Springer
Widespread alterations in the expression of various genes could contribute to the
pathogenesis of epilepsy. The expression levels of various genes, including major inhibitory …