Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications
Major depressive disorder (MDD) was previously hypothesized to be a disease of
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …
Formation and integration of new neurons in the adult hippocampus
A Denoth-Lippuner, S Jessberger - Nature Reviews Neuroscience, 2021 - nature.com
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …
Integrating spatial and single-nucleus transcriptomic data elucidates microglial-specific responses in female cynomolgus macaques with depressive-like behaviors
J Wu, Y Li, Y Huang, L Liu, H Zhang, C Nagy… - Nature …, 2023 - nature.com
Major depressive disorder represents a serious public health challenge worldwide;
however, the underlying cellular and molecular mechanisms are mostly unknown. Here, we …
however, the underlying cellular and molecular mechanisms are mostly unknown. Here, we …
Animal models of major depression: drawbacks and challenges
Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
Microglia in depression: current perspectives
Major depressive disorder (MDD) is a prevalent psychiatric disease that involves
malfunctions of different cell types in the brain. Accumulating studies started to reveal that …
malfunctions of different cell types in the brain. Accumulating studies started to reveal that …
The role of adult hippocampal neurogenesis in brain health and disease
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …
Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by
environmental influences, and functionally implicated in behavioural responses to stress …
environmental influences, and functionally implicated in behavioural responses to stress …
Sex differences in depression: Insights from clinical and preclinical studies
Depression represents a global mental health concern, and disproportionally affects women
as they are twice more likely to be diagnosed than men. In this review, we provide a …
as they are twice more likely to be diagnosed than men. In this review, we provide a …
Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice
E Siopi, M Galerne, M Rivagorda, S Saha… - Molecular …, 2023 - nature.com
Chronic stress constitutes a major risk factor for depression that can disrupt various aspects
of homeostasis, including the gut microbiome (GM). We have recently shown that GM …
of homeostasis, including the gut microbiome (GM). We have recently shown that GM …
Adult hippocampal neurogenesis and cognitive flexibility—linking memory and mood
Adult hippocampal neurogenesis has been implicated in cognitive processes, such as
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …