Background Chronic pain conditions impose significant burdens worldwide.
Pharmacological treatments like opioids have limitations. Non-invasive non …

Migraine is a common, chronic, disorder that is typically characterized by recurrent disabling
attacks of headache and accompanying symptoms, including aura. The aetiology is …

Migraine is a complex condition in which genetic predisposition interacts with other
biological and environmental factors determining its course. A hyperresponsive brain cortex …

Background Several drugs are available for the preventive treatment of both episodic and
chronic migraine. The choice of which therapy to initiate first, second, or third is not …

Background PROMISE-2 was a phase 3, randomized, double-blind, placebo-controlled
study that evaluated the efficacy and safety of repeat intravenous (IV) doses of the calcitonin …

During a 1-year compassionate use program, 156 patients with migraine self-administered a
monthly dose of erenumab 140 mg with a subcutaneous autoinjector. Main inclusion criteria …

Background Migraine affects 1.1 billion people globally and is the second leading cause of
disability worldwide. In clinical trials, treatment efficacy is evaluated by comparing the …

Background Chronic migraine (CM) is a disabling condition with high prevalence in the
general population. Until the recent approval of monoclonal antibodies targeting the …

Importance Patients with chronic migraine and medication overuse headaches (CM-MOH)
represent a particularly burdened subpopulation. This trial provides first, to our knowledge …

Migraine is a headache disorder associated with a high socioeconomic burden. The digital
therapeutic sinCephalea provides an individualized low-glycemic diet based on continuous …