Neutrophils at the crossroads of innate and adaptive immunity
C Rosales - Journal of Leucocyte Biology, 2020 - academic.oup.com
Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly
mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display …
mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display …
Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation
T Chavakis, I Mitroulis, G Hajishengallis - Nature immunology, 2019 - nature.com
Recent advances have highlighted the ability of hematopoietic stem and progenitor cells in
the bone marrow to sense peripheral inflammation or infection and adapt through increased …
the bone marrow to sense peripheral inflammation or infection and adapt through increased …
Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection
The full neutrophil heterogeneity and differentiation landscape remains incompletely
characterized. Here, we profiled> 25,000 differentiating and mature mouse neutrophils using …
characterized. Here, we profiled> 25,000 differentiating and mature mouse neutrophils using …
MDSCs: key criminals of tumor pre-metastatic niche formation
Y Wang, Y Ding, N Guo, S Wang - Frontiers in immunology, 2019 - frontiersin.org
The emergence of disseminated metastases remains the primary cause of mortality in
cancer patients. Formation of the pre-metastatic niche (PMN), which precedes the …
cancer patients. Formation of the pre-metastatic niche (PMN), which precedes the …
The ontogeny of a neutrophil: mechanisms of granulopoiesis and homeostasis
Comprising the majority of leukocytes in humans, neutrophils are the first immune cells to
respond to inflammatory or infectious etiologies and are crucial participants in the proper …
respond to inflammatory or infectious etiologies and are crucial participants in the proper …
Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration
SAC McDowell, RBE Luo, A Arabzadeh, S Doré… - Nature cancer, 2021 - nature.com
Metastasis is the leading cause of cancer-related deaths, and obesity is associated with
increased breast cancer (BC) metastasis. Preclinical studies have shown that obese …
increased breast cancer (BC) metastasis. Preclinical studies have shown that obese …
Regulation of inflammation-and infection-driven hematopoiesis
S Boettcher, MG Manz - Trends in immunology, 2017 - cell.com
Innate myeloid immune cells, and neutrophils in particular, serve as first line of defense
against pathogenic microorganisms including bacteria and fungi. Given their short life span …
against pathogenic microorganisms including bacteria and fungi. Given their short life span …
Dynamic responses of the haematopoietic stem cell niche to diverse stresses
Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal
and haematopoietic cells regulate their function. The steady state HSC niche has been …
and haematopoietic cells regulate their function. The steady state HSC niche has been …
Regulation of emergency granulopoiesis during infection
During acute infectious and inflammatory conditions, a large number of neutrophils are in
high demand as they are consumed in peripheral organs. The hematopoietic system rapidly …
high demand as they are consumed in peripheral organs. The hematopoietic system rapidly …
Regulation of the bone marrow niche by inflammation
I Mitroulis, L Kalafati, M Bornhäuser… - Frontiers in …, 2020 - frontiersin.org
Hematopoietic stem cells (HSC) reside in the bone marrow (BM) within a specialized micro-
environment, the HSC niche, which comprises several cellular constituents. These include …
environment, the HSC niche, which comprises several cellular constituents. These include …