Taxanes are standard treatment for metastatic breast cancer; however, the solvents used as
vehicles in these formulations cause severe toxicities. The FDA recently approved a solvent …

Modulation of neurotransmitter release by G-protein-coupled receptors (GPCRs) is a
prominent presynaptic mechanism for regulation of synaptic transmission. Activation of …

Endocannabinoids play an important role in a diverse range of neurophysiological
processes including neural development, neuroimmune function, synaptic plasticity, pain …

Drugs that interfere with cannabinoid CB1 transmission suppress various food-motivated
behaviors, and it has been suggested that such drugs could be useful as appetite …

Oligonucleotide (ON) therapeutics are emerging as a new generation of medicine with
tremendous potential, but their clinical translation is hampered by inferior stability and short …

Cannabinoid (CB) 1 receptor inverse agonists inhibit food intake in animals and humans but
also potentiate emesis. It is not clear whether these effects result from inverse agonist …

Depolarization-induced suppression of inhibition (DSI) or excitation (DSE) is a well-known
form of endocannabinoid-mediated short-term plasticity that is induced by postsynaptic …

Key points• 2‐Arachidonoylglycerol (2‐AG), one of the best‐characterized retrograde
messengers at central synapses, has been thought to be produced 'on demand'through a …

My involvement with the field of cannabinoids spans close to 3 decades and covers a major
part of my scientific career. It also reflects the robust progress in this initially largely …

Introduction: The endocannabinoids (eCBs), 2-arachidonoylglycerol (2-AG) and
arachidonoyl ethanolamine (AEA), are produced by separate enzymatic pathways, activate …