Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

Background The DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT)
causes resistance of tumor cells to alkylating agents. It is a predictive biomarker in high …

Abstract Background Glioblastoma multiforme (GBM, World Health Organization [WHO]
grade IV) is one of the malignant Central Nerve System (CNS) tumors with high incidence …

Glioblastoma (GBM) is the most common and aggressive form of brain cancer in adults,
characterized by extensive growth, a high recurrence rate, and resistance to treatment …

Brusatol (Bru), a Chinese herbal extract, has a variety of anti-tumor effects. However, little is
known regarding its role and underlying mechanism in glioblastoma cells. Here, we found …

Background/purpose Glioblastoma (GBM) is the most common primary malignant brain
tumor. Sex has been shown to be an important prognostic factor for GBM. The purpose of …

Temozolomide (TMZ) is the primary chemotherapeutic drug for treating glioblastoma (GBM);
however, the final clinical outcome is considerably limited by the poor response and …

Glioblastoma, the most common primary malignant tumor of the central nervous system in
adults, is also among the most lethal. Despite a comprehensive treatment approach which …

MGMT promoter methylation is related to the increased sensitivity of tumour tissue to
chemotherapy with temozolomide (TMZ) and thus to improved patient survival. However, it is …

Background Early detection of treatment response is important for the management of
patients with malignant brain tumors such as glioblastoma to assure good quality of life in …