Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …

Musculoskeletal pain is a condition that characterises several diseases and represents a
constantly growing issue with enormous socio-economic burdens, highlighting the …

Knowledge about the mechanisms of transmission and the processing of nociceptive
information, both in healthy and pathological states, has greatly expanded in recent years …

Fabry disease (FD) is a life-threatening X-linked lysosomal storage disorder caused by α-
galactosidase A (α-GAL) deficiency. Small fiber pathology and pain are major FD symptoms …

Inflammation is the consequence of dry eye disease regardless of its etiology. Several
injurious or harmless processes to the ocular surface neurons promote ocular surface …

Microtubule targeting agents (MTAs) are anticancer therapies commonly prescribed for
breast cancer and other solid tumors. Sensory peripheral neuropathy (PN) is the major dose …

Chronic pain is a life-altering condition affecting millions of people. Current treatments are
inadequate and prolonged therapies come with severe side effects, especially dependence …

Peripheral denervation and pain are hallmarks of small fiber neuropathy (SFN). We
investigated the contribution of skin cells on nociceptor degeneration and sensitization. We …

The first symptom arising in many Fabry patients is neuropathic pain due to changes in small
myelinated and unmyelinated fibers in the periphery, which is subsequently followed by a …

The bioactive sphingolipid metabolite, sphingosine 1-phosphate (S1P), and the signaling
pathways triggered by its binding to specific G protein-coupled receptors play a critical …