More than 350 individual MYPBC3 mutations have been identified in patients with inherited
hypertrophic cardiomyopathy (HCM), thus representing 40–50% of all HCM mutations …

Two groundbreaking papers published in 1954 laid out the theory of the mechanism of
muscle contraction based on force-generating interactions between myofilaments in the …

Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction,
can alter power output and cause cardiomyopathy. However, measurements of the intrinsic …

Mutations in cardiac myosin binding protein C (MyBP-C, encoded by MYBPC3) are the most
common cause of hypertrophic cardiomyopathy (HCM). Most MYBPC3 mutations result in …

Although several ribosomal protein paralogs are expressed in a tissue-specific manner, how
these proteins affect translation and why they are required only in certain tissues have …

The heart is an extraordinarily versatile pump, finely tuned to respond to a multitude of
demands. Given the heart pumps without rest for decades its efficiency is particularly …

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are considered
immature in the sarcomere organization, contractile machinery, calcium transient, and …

During each heartbeat, cardiac contractility results from calcium-activated sliding of actin thin
filaments toward the centers of myosin thick filaments to shorten cellular length. Cardiac …

Background: Pathogenic variants in MYBPC3, encoding cardiac MyBP-C (myosin binding
protein C), are the most common cause of familial hypertrophic cardiomyopathy. A large …

Mutations in atrial-enriched genes can cause a primary atrial myopathy that can contribute to
overall cardiovascular dysfunction. MYBPHL encodes myosin-binding protein H-like (MyBP …