We have come a long way in the last years of developing analytical strategies in
metabolomics. We have seen huge progress in tackling multiplatform measurement, data …

Background SARS-CoV-2 infection causes acute respiratory distress, which may progress to
multiorgan failure and death. Severe COVID-19 disease is accompanied by reduced …

Matrix-assisted laser desorption–ionization mass spectrometry imaging in transmission-
mode geometry (t-MALDI–MSI) can provide molecular information with a pixel size of 1 µm …

Lysosomes serve dual antagonistic functions in cells by mediating anabolic growth signaling
and the catabolic turnover of macromolecules. How these janus-faced activities are …

Over the past decade, mass spectrometry (MS)-based “shotgun lipidomics” has emerged as
a powerful tool for quantitative and qualitative analysis of the complex lipids in the biological …

Nonalcoholic fatty liver disease (NAFLD) is a common metabolic dysfunction leading to
hepatic steatosis. However, NAFLD's global impact on the liver lipidome is poorly …

Mitochondria are central for cellular metabolism and energy supply. Barth syndrome (BTHS)
is a severe disorder, due to dysfunction of the mitochondrial cardiolipin acyl transferase …

Direct infusion‐based shotgun lipidomics is one of the most powerful and useful tools in
comprehensive analysis of lipid species from lipid extracts of various biological samples with …

Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS
defects lead to severe human disorders with unexplained tissue specific pathologies …

How cold-blooded animals acclimate to temperature and what determines the limits of their
viable temperature range are not understood. Here, we show that Drosophila alter their …