Covering: up to the end of 2020 Nonribosomal peptide synthetases are remarkable
molecular machines that produce a wide range of structurally complex peptide natural …

Cyanobacteria of the genus Nostoc are widespread in all kinds of habitats. They occur in a
free-living state or in association with other organisms. Members of this genus belong to …

Non-ribosomal peptide synthetases (NRPSs) are attractive targets for biosynthetic pathway
engineering due to their modular architecture and the therapeutic relevance of their …

Nonribosomal peptide synthetases (NRPSs) are involved in the biosynthesis of numerous
peptide and peptide-like natural products that have been exploited in medicine, agriculture …

Protein-reactive natural products such as the fungal metabolite cerulenin are recognized for
their value as therapeutic candidates, due to their ability to selectively react with catalytic …

Cinnamoyl-containing nonribosomal peptides (CCNPs) constitute a unique family of natural
products. The enzyme mechanism for the biaryl phenol coupling reaction of the bicyclic …

About 70% of the drugs in use are derived from natural products, either used directly or in
chemically modified form. Among all possible small molecules (not greater than 5 kDa), only …

Nonribosomal peptide synthetases (NRPSs) are complex multi-modular enzymes containing
catalytic domains responsible for the loading and incorporation of amino acids into natural …

The diverse microbes that produce natural products represent an important source of novel
therapeutics, drug leads, and scientific tools. However, the vast majority have not been …

Precursor-directed biosynthesis was used to generate a series of fluorinated verticillins. The
biosynthesis of these epipolythiodioxopiperazine alkaloids was monitored in situ via the …