T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …

Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in
diverse biological processes, including different aspects of immune functions. Ubiquitination …

Deubiquitinating enzymes, or DUBs, comprise a family of proteases that regulate
ubiquitination dynamics. Since their discovery, genetic and functional studies have …

Ubiquitination plays a central role in the regulation of various biological functions including
immune responses. Ubiquitination is induced by a cascade of enzymatic reactions by E1 …

The prevalence of diabetes mellitus is increasing globally. Probiotics have been shown to
be an effective intervention for diabetes. This study focused on the relieving effects and …

The innate immune system protects the host from external pathogens and internal damage
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …

The ubiquitin proteasome system (UPS) is a proteolytic machinery for the degradation of
protein substrates that are post-translationally conjugated with ubiquitin polymers through …

Deubiquitylating enzymes (DUBs) play a vital role in the ubiquitin pathway by editing or
removing ubiquitin from their substrate. As breakthroughs within the ubiquitin field continue …

Signal transduction from the T cell receptor (TCR) is crucial for T cell–mediated immune
responses and, when deregulated, also contributes to the development of autoimmunity …

Abstract Deubiquitinating enzymes (DUBs),~ 100 of which are found in human cells, are
proteases that remove ubiquitin conjugates from proteins, thereby regulating protein …