Until recently, it was considered unethical or impossible to perform clinical trials of new
medicines in children. As a consequence, many medicines used for treating children are …

The aim was to compare results of studies performed in different settings worldwide and
identify common therapeutic areas to allow for focused interventions, because off-label drug …

To date, the lack of age-appropriate medicines for many indications results in dose
manipulation of commercially available dosage forms, commonly resulting in inaccurate …

The pharmacist, both in community and hospital pharmacy practice, is often challenged with
the preparation of a liquid dosage form not available commercially for paediatric patients …

An innovative pediatric oral formulation of hydrochlorothiazide (HCT)(2 mg/mL), endowed
with improved bioavailability and sustained release properties and suitable for the …

Background: Many medicines used in newborns, infants, children and adolescents are not
licensed (“unlicensed”) or are prescribed outside the terms of the marketing authorization …

The use of unlicensed and off-label medicines in neonates in intensive care is common and
widespread. Up to 93% of babies receive at least one unlicensed or off-label medicine …

Aim This study provided an overview of manipulating oral medicines given to hospitalised
children and evaluated this practice in two hospitals. It focused on the type of manipulation …

For centuries, the pharmaceutical profession has provided services of fundamental value to
society, such as the procurement, storage, compounding and dispensing of drugs. In recent …

Suitable dosage forms are not always available for specific patient populations and must be
extemporaneously compounded. Extemporaneous preparation is the manipulation of drugs …