[HTML][HTML] Dual-specificity MAP kinase phosphatases in health and disease
It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play
key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in …
key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in …
An update on emerging immunological targets and their inhibitors in the treatment of psoriasis
S Parab, G Doshi - International immunopharmacology, 2022 - Elsevier
Psoriasis is a non-communicable, heterogeneous, autoimmune, inflammatory skin disease
characterised by reddish, scaly plaques that grow over time. Psoriasis affects people in all …
characterised by reddish, scaly plaques that grow over time. Psoriasis affects people in all …
Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of Cimicifugae Rhizoma-Smilax glabra Roxb herb pair for the …
XQ Hu, C Qi, F Feng, Y Wang, TT Di, YJ Meng, Y Wang… - Phytomedicine, 2022 - Elsevier
Background Psoriasis is a prevalent chronic inflammatory skin condition marked by immune
cell infiltration and keratinocyte abnormal proliferation. Cimicifugae Rhizoma-Smilax glabra …
cell infiltration and keratinocyte abnormal proliferation. Cimicifugae Rhizoma-Smilax glabra …
[HTML][HTML] Immunogenetic variations predict immune-related adverse events for PD-1/PD-L1 inhibitors
Z Xin, L You, F Na, J Li, M Chen, J Song, L Bai… - European Journal of …, 2023 - Elsevier
Abstract Background PD-1/PD-L1 inhibitors have brought remarkable benefits but can cause
profound immune-related adverse events (irAEs). The host immunogenetic background is …
profound immune-related adverse events (irAEs). The host immunogenetic background is …
Ghrelin protects against contact dermatitis and psoriasiform skin inflammation by antagonizing TNF-α/NF-κB signaling pathways
R Qu, X Chen, J Hu, Y Fu, J Peng, Y Li, J Chen, P Li… - Scientific Reports, 2019 - nature.com
Contact dermatitis and psoriasis are skin disorders caused by immune dysregulation, yet
much remains unknown about their underlying mechanisms. Ghrelin, a recently discovered …
much remains unknown about their underlying mechanisms. Ghrelin, a recently discovered …
Complexities in genetics of psoriatic arthritis
Abstract Purpose of the Review To provide a general overview and current challenges
regarding the genetics of psoriatic disease. With the use of integrative medicine, multiple …
regarding the genetics of psoriatic disease. With the use of integrative medicine, multiple …
Psoriasiform inflammation is associated with mitochondrial fission/GDAP1L1 signaling in macrophages
A Alalaiwe, CY Chen, ZY Chang, JT Sung… - International Journal of …, 2021 - mdpi.com
While psoriasis is known as a T cell-and dendritic cell-driven skin inflammation disease,
macrophages are also reported to play some roles in its development. However, the …
macrophages are also reported to play some roles in its development. However, the …
2,4-Dimethoxy-6-Methylbenzene-1,3-diol, a Benzenoid From Antrodia cinnamomea, Mitigates Psoriasiform Inflammation by Suppressing MAPK/NF-κB …
SY Chuang, CY Chen, SC Yang, A Alalaiwe… - Frontiers in …, 2021 - frontiersin.org
Antrodia cinnamomea exhibits anti-inflammatory, antioxidant, and immunomodulatory
activities. We aimed to explore the antipsoriatic potential of 2, 4-dimethoxy-6-methylbenzene …
activities. We aimed to explore the antipsoriatic potential of 2, 4-dimethoxy-6-methylbenzene …
p38α deficiency ameliorates psoriasis development by downregulating STAT3-mediated keratinocyte proliferation and cytokine production
T Zheng, J Deng, J Wen, S Xiao, H Huang… - Communications …, 2024 - nature.com
Psoriasis is characterized by keratinocyte (KC) hyperproliferation and inflammatory cell
infiltration, but the mechanisms remain unclear. In an imiquimod-induced mouse …
infiltration, but the mechanisms remain unclear. In an imiquimod-induced mouse …
[PDF][PDF] 单味中药调控MAPK 信号通路在银屑病中的研究进展
万新， 曾三武 - 中成药, 2023 - pmt5b327c.pic7.websiteonline.cn
银屑病是临床上一种常见的慢性炎症性反复发作性皮肤病, 是以角质细胞过度增殖,
炎性细胞浸润, 真皮血管新生为主要特征的皮肤疾病, 在世界范围内有1%~ 2% 的发病率 …
炎性细胞浸润, 真皮血管新生为主要特征的皮肤疾病, 在世界范围内有1%~ 2% 的发病率 …