Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells
U Testa, E Pelosi, G Castelli - Medical Sciences, 2018 - mdpi.com
Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
A risk-stratified approach to colorectal cancer prevention and diagnosis
Population screening and endoscopic surveillance are used widely to prevent the
development of and death from colorectal cancer (CRC). However, CRC remains a major …
development of and death from colorectal cancer (CRC). However, CRC remains a major …
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
Mutation accumulation in somatic cells contributes to cancer development and is proposed
as a cause of aging. DNA polymerases Pol ε and Pol δ replicate DNA during cell division …
as a cause of aging. DNA polymerases Pol ε and Pol δ replicate DNA during cell division …
The co-evolution of the genome and epigenome in colorectal cancer
T Heide, J Househam, GD Cresswell, I Spiteri, C Lynn… - Nature, 2022 - nature.com
Colorectal malignancies are a leading cause of cancer-related death and have undergone
extensive genomic study,. However, DNA mutations alone do not fully explain malignant …
extensive genomic study,. However, DNA mutations alone do not fully explain malignant …
[HTML][HTML] Integrated analysis of colorectal cancer microRNA datasets: Identification of microRNAs associated with tumor development
Colorectal cancer (CRC) is one of the leading cause of cancer death worldwide. Currently,
no effective early diagnostic biomarkers are available for colorectal carcinoma. Therefore …
no effective early diagnostic biomarkers are available for colorectal carcinoma. Therefore …
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
Cellular DNA damage caused by reactive oxygen species is repaired by the base excision
repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic …
repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic …
Genetic and epigenetic dependencies in colorectal cancer development
S Parmar, H Easwaran - Gastroenterology Report, 2022 - academic.oup.com
Recent studies have mapped key genetic changes in colorectal cancer (CRC) that impact
important pathways contributing to the multistep models for CRC initiation and development …
important pathways contributing to the multistep models for CRC initiation and development …
Immune activation in mismatch repair–deficient carcinogenesis: More than just mutational rate
JA Willis, L Reyes-Uribe, K Chang, SM Lipkin… - Clinical Cancer …, 2020 - AACR
Mismatch repair (MMR)–deficient colorectal cancers (dMMR colorectal cancer) are
characterized by the expression of highly immunogenic neoantigen peptides, which …
characterized by the expression of highly immunogenic neoantigen peptides, which …
TELO2 induced progression of colorectal cancer by binding with RICTOR through mTORC2
Z Guo, X Zhang, H Zhu, N Zhong, X Luo… - Oncology …, 2021 - spandidos-publications.com
Colorectal cancer (CRC) is a common cancer worldwide, and its treatment strategies are
limited. The underlying mechanism of CRC progression remains to be determined …
limited. The underlying mechanism of CRC progression remains to be determined …
The majority of β-catenin mutations in colorectal cancer is homozygous
A Arnold, M Tronser, C Sers, A Ahadova, V Endris… - BMC cancer, 2020 - Springer
Background β-catenin activation plays a crucial role for tumourigenesis in the large intestine
but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin …
but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin …