Systems Biology in Cancer Diagnosis Integrating Omics Technologies and Artificial Intelligence to Support Physician Decision Making

A Fawaz, A Ferraresi, C Isidoro - Journal of Personalized Medicine, 2023 - mdpi.com
Cancer is the second major cause of disease-related death worldwide, and its accurate
early diagnosis and therapeutic intervention are fundamental for saving the patient's life …

Evaluation and management of insomnia in the clinical practice in Italy: a 2023 update from the Insomnia Expert Consensus Group

L Palagini, R Manni, C Liguori, L De Gennaro… - Journal of …, 2024 - Springer
Background Insomnia is the most reported sleep disorder in industrialized countries,
affecting, in the chronic form, around 10% of the European population. In Italy, such a …

[HTML][HTML] Delphi consensus recommendations for the management of chronic insomnia in Canada

CM Morin, A Khullar, R Robillard, A Desautels… - Sleep Medicine, 2024 - Elsevier
Objective The lack of current Canadian practice guidelines for the management of insomnia
poses a challenge for healthcare providers (HCP) in selecting the appropriate treatment …

[HTML][HTML] Daridorexant in Japanese patients with insomnia disorder: A phase 3, randomized, double-blind, placebo-controlled study

N Uchimura, M Taniguchi, Y Ariyoshi, Y Oka, O Togo… - Sleep Medicine, 2024 - Elsevier
Abstract Objective This Phase 3 double-blind, placebo-controlled study evaluated the
efficacy and safety of daridorexant in Japanese patients with insomnia disorder …

Digital cognitive–behavioural therapy application compared with zolpidem for the treatment of insomnia: protocol for an exploratory randomised controlled trial

E Shimizu, D Sato, Y Hirano, H Ebisu, Y Kagayama… - BMJ open, 2024 - bmjopen.bmj.com
Introduction Insomnia is a common health problem and cognitive–behavioural therapy
(CBT) is recommended as a treatment. As there is a critical shortage of CBT-trained …

Medical professionals and pharmacological intervention for the treatment of insomnia: a cross-sectional study

A Liaskopoulos, V Kakouris, N Liaskopoulos… - Sleep …, 2024 - thieme-connect.com
Objective To explore the preferences of medical practitioners concerning various
medications and other remedies to manage insomnia, and to ascertain whether these …

Pharmacological Treatments of Sleep–Wake Disorders: Update 2023

MS Kallweit, NP Kallweit, U Kallweit - Clinical and Translational …, 2023 - mdpi.com
Biological, environmental, behavioral, and social factors can influence sleep and lead to
sleep disorders or diseases. Sleep disorders are common, numerous, and heterogeneous in …

Factors associated with hypnotics polypharmacy in the Japanese population

A Shimura, Y Takaesu, K Sugiura, S Takagi, Y Okawa… - Sleep Medicine, 2024 - Elsevier
Objective Insomnia disorder is a global public health issue, commonly treated with
hypnotics. However, long-term use of benzodiazepine derivatives (BZDs), especially …

Evaluation of prescribing patterns of switching to and add-on lemborexant in patients treated with hypnotic medication: a nationwide claims database study in Japan

S Tanaka-Mizuno, K Fujimoto, K Mishima… - Expert Opinion on …, 2024 - Taylor & Francis
Background When considering changing hypnotic pharmacotherapy, lemborexant has
attracted attention as a candidate due to its effectiveness and safety profile. However, few …

Efficacy and Safety of Transitioning to Lemborexant from Z-drug, Suvorexant, and Ramelteon in Japanese Insomnia Patients: An Open-label, Multicenter Study

M Ozone, S Hirota, Y Ariyoshi, K Hayashida… - Advances in …, 2024 - Springer
Introduction For patients with chronic insomnia, conventional therapy may not always
provide satisfactory efficacy and safety. Thus, switching to an alternative therapeutic agent …