KCNMA1 encodes the pore-forming α subunit of the “Big K+”(BK) large conductance calcium
and voltage-activated K+ channel. BK channels are widely distributed across tissues …

Hyperaldosteronism, a common cause of hypertension, is strongly connected to Na+, K+,
and Mg2+ dysregulation. Owing to its steroidal structure, aldosterone is an active …

Patients with end-stage renal disease (ESRD) on maintenance dialysis have a high risk of
developing hyperkalemia, generally defined as serum potassium (K+) concentrations of> 5.0 …

Mice lacking the β1-subunit (gene, Kcnmb1; protein, BK-β1) of the large Ca-activated K
channel (BK) are hypertensive. This phenotype is thought to result from diminished BK …

The large-conductance voltage and calcium-sensitive BK channel is important in many
electrically active cells. Its unique sensitivity to both intracellular calcium levels and …

Homeostatic control of plasma K+ is a necessary physiological function. The daily dietary K+
intake of~ 100 mmol is excreted predominantly by the distal tubules of the kidney. About …

Cholesterol (CLR) is an essential component of eukaryotic plasma membranes. CLR
regulates the membrane physical state, microdomain formation and the activity of membrane …

Classical physiological analysis of electrolyte handling in knockout mice has enlightened
our understanding of the mechanism of handling K loads by renal K channels. Studies have …

Potassium is a major intracellular cation in the body, regulating membrane potential of
excitable cells, such as cardiomyocytes and skeletal muscle cells. Because the kidney plays …

The colon has large capacities for K+ absorption and K+ secretion, but its role in maintaining
K+ homeostasis is often overlooked. For many years, passive diffusion and/or solvent drag …