Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …

Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …

Background Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …

Lipid droplet (LD) lipolysis in brown adipose tissue (BAT) is generally considered to be
required for cold-induced nonshivering thermogenesis. Here, we show that mice lacking …

Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous
compounds, including lipid esters. Physiological functions of carboxylesterases in lipid …

A variant (148M) in patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) is a
major risk factor for fatty liver disease. Despite its clinical importance, the pathogenic …

Lipid droplets (LDs) are ubiquitous cellular organelles for lipid storage which are composed
of a neutral lipid core bounded by a protein decorated phospholipid monolayer. Although …

Recent studies have identified a genetic variant rs641738 near two genes encoding
membrane bound O-acyltransferase domain-containing 7 (MBOAT7) and transmembrane …

Lipid droplets (LDs) are key subcellular organelles for regulating lipid metabolism. Although
several subcellular organelles participate in lipid metabolism, it remains elusive whether …

Patatin-like phospholipase-domain-containing 2 (PNPLA2; also known as adipose
triglyceride lipase, ATGL) and PNPLA3 (also known as adiponutrin) are encoded by close …