Nutrient-driven dedifferentiation of enteroendocrine cells promotes adaptive intestinal growth in Drosophila

H Nagai, LAE Nagai, S Tasaki, R Nakato, D Umetsu… - Developmental Cell, 2023 - cell.com
Post-developmental organ resizing improves organismal fitness under constantly changing
nutrient environments. Although stem cell abundance is a fundamental determinant of …

A distinct Acyl-CoA binding protein (ACBP6) shapes tissue plasticity during nutrient adaptation in Drosophila

X Li, J Karpac - Nature Communications, 2023 - nature.com
Nutrient availability is a major selective force in the evolution of metazoa, and thus plasticity
in tissue function and morphology is shaped by adaptive responses to nutrient changes …

Cell-fate conversion of intestinal cells in adult Drosophila midgut by depleting a single transcription factor

X Guo, C Wang, Y Zhang, R Wei, R Xi - Nature Communications, 2024 - nature.com
The manipulation of cell identity by reprograming holds immense potential in regenerative
medicine, but is often limited by the inefficient acquisition of fully functional cells. This …

A perspective on Drosophila genetics and its insight into human neurodegenerative disease

NM Bonini - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Drosophila has been long appreciated as a classic genetic system for its ability to define
gene function in vivo. Within the last several decades, the fly has also emerged as a …

Seasonal variation in endoreduplication and polyteny in the fruit fly Drosophila melanogaster (Diptera: Drosophilidae): How does it contribute to adaptation?

V STRASHNYUK, E VAKULENKO, Y KOPTEVTSOVA - EJE, 2025 - eje.cz
In temperate regions, the fruit fly Drosophila melanogaster (Meigen, 1830) is subject to
seasonal changes in natural conditions. Insects exhibit a wide range of adaptive responses …

Highly regenerative species-specific genes improve age-associated features in the adult Drosophila midgut

H Nagai, Y Adachi, T Nakasugi, E Takigawa, J Ui… - BMC biology, 2024 - Springer
Background The remarkable regenerative abilities observed in planarians and cnidarians
are closely linked to the active proliferation of adult stem cells and the precise differentiation …

Editorial note: flying high in Japan

R Niwa, M Sato, T Igaki - Fly, 2023 - Taylor & Francis
In 1922, Professor Yoshimaro Tanaka at Kyushu University introduced Drosophila
melanogaster as a model organism for research in Japan, importing the flies from the …

Nutrient-driven dedifferentiation of enteroendocrine cells promotes adaptive intestinal growth

H Nagai, LAE Nagai, S Tasaki, R Nakato, D Umetsu… - bioRxiv, 2023 - biorxiv.org
Post-developmental organ resizing improves organismal fitness under constantly changing
nutrient environments. Although stem cell abundance is a fundamental determinant of …