Improvement of quality of life and survival of cancer patients will be greatly enhanced by the
development of highly effective drugs to selectively kill malignant cells. Artemisinin and its …

In this tutorial review, an effort towards presentation of a comprehensive account of the
recent developments on various kinds of artemisinin derivatives including artemisinin …

Artemisinin contains an endoperoxide moiety that can react with iron to form cytotoxic free
radicals. Cancer cells contain significantly more intracellular free iron than normal cells and …

The emergence of drug-resistance and the low specificity of anticancer agents are the major
challenges in the treatment of cancer and can result in many side effects, creating an urgent …

Sesquiterpene lactones are of considerable interest due to their potent bioactivities,
including cancer cell cytotoxicity and antineoplastic efficacy in in vivo studies. Among these …

Background: Artemisinin is a sesquiterpene lactone compound with a special peroxide
bridge that is tightly linked to the cytotoxicity involved in fighting malaria and cancer …

The development of new efficient therapeutics for the treatment of malaria and cancer is an
important endeavor. Over the past 15 years, much attention has been paid to the synthesis …

Heme is not only just the binding site responsible for oxygen transport by hemoglobin, but it
is also the prosthetic group of many different heme-containing enzymes, such as …

Stable tricyclic aminoperoxides can be selectively assembled via a catalyst-free three-
component condensation of β, δ′-triketones, H2O2, and an NH-group source such as …

In our ongoing search for highly active hybrid molecules exceeding their parent compounds
in anticancer, antimalaria as well as antiviral activity and being an alternative to the standard …