Conspectus γ, δ-Unsaturated ketones, so-called homoallylic ketones, have served as
versatile building blocks for the synthesis of a variety of heterocycles, carbocycles, natural …

Allosteric modulators (AMs) of G-protein coupled receptors (GPCRs) are desirable drug
targets because they can produce fewer on-target side effects, improved selectivity, and …

While the urotensinergic system plays a role in influencing various pathologies, its potential
remains untapped because of the absence of therapeutically effective urotensin II receptor …

In accordance with their common but also divergent physiological actions, human urotensin
II (1) and urotensin II-related peptide (2) could stabilize specific urotensin II receptor (UTR) …

Urotensin II (UII) and urotensin II-related peptide (URP) are functionally selective,
suggesting that these two hormones might play distinct physiological role through different …

The urotensinergic system, involved in the development and/or progression of numerous
pathological conditions, is composed of one G protein-coupled receptor (UT) and two …

The urotensinergic system, comprised of a G protein-coupled receptor (UT) and two
endogenous ligands named urotensin II (UII) and urotensin II-related peptide (URP), has …

Over the last decade, the urotensinergic system, composed of one G protein-coupled
receptor and two endogenous ligands, has garnered significant attention as a promising …

In the past few years, we have identified two allosteric modulators of the urotensinergic
system with probe-dependent action, termed Urocontrin (UC) and Urocontrin A (UCA). Such …

Over the last decade, the urotensinergic system has garnered significant attention as a
promising new target for the treatment of various cardiovascular diseases and also cancer …