[HTML][HTML] Extracellular vesicles: new classification and tumor immunosuppression
Simple Summary Extracellular vesicles (EVs) are cell-derived membrane-surrounded
vesicles that carry bioactive molecules and deliver them to recipient cells. Classical EVs are …
vesicles that carry bioactive molecules and deliver them to recipient cells. Classical EVs are …
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies
MR Chaudhary, S Chaudhary, Y Sharma, TA Singh… - Biogerontology, 2023 - Springer
Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …
biological progression involving various genetic, environmental, and lifestyle factors. The …
Proteotoxic stress is a driver of the loser status and cell competition
ME Baumgartner, MP Dinan, PF Langton… - Nature Cell …, 2021 - nature.com
Cell competition allows winner cells to eliminate less fit loser cells in tissues. In Minute cell
competition, cells with a heterozygous mutation in ribosome genes, such as RpS3+/− cells …
competition, cells with a heterozygous mutation in ribosome genes, such as RpS3+/− cells …
Inhibitors of the ATPase p97/VCP: From basic research to clinical applications
Protein homeostasis deficiencies underlie various cancers and neurodegenerative
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …
[HTML][HTML] Build-UPS and break-downs: metabolism impacts on proteostasis and aging
F Ottens, A Franz, T Hoppe - Cell Death & Differentiation, 2021 - nature.com
Perturbation of metabolism elicits cellular stress which profoundly modulates the cellular
proteome and thus protein homeostasis (proteostasis). Consequently, changes in the …
proteome and thus protein homeostasis (proteostasis). Consequently, changes in the …
[HTML][HTML] Proteotoxic stress and cell death in cancer cells
C Brancolini, L Iuliano - Cancers, 2020 - mdpi.com
To maintain proteostasis, cells must integrate information and activities that supervise
protein synthesis, protein folding, conformational stability, and also protein degradation …
protein synthesis, protein folding, conformational stability, and also protein degradation …
Proteasome inhibitors as anticancer agents
G Gazzaroli, A Angeli, A Giacomini… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The therapeutic targeting of the ubiquitin-proteasome pathway (UPP) through
inhibitors of the 20S proteasome core proteolytic activities has revolutionized the treatment …
inhibitors of the 20S proteasome core proteolytic activities has revolutionized the treatment …
[HTML][HTML] Cell stress induced stressome release including damaged membrane vesicles and extracellular HSP90 by prostate cancer cells
Tumor cells exhibit therapeutic stress resistance-associated secretory phenotype involving
extracellular vesicles (EVs) such as oncosomes and heat shock proteins (HSPs). Such a …
extracellular vesicles (EVs) such as oncosomes and heat shock proteins (HSPs). Such a …
[HTML][HTML] Roles of CNC transcription factors NRF1 and NRF2 in cancer
H Sekine, H Motohashi - Cancers, 2021 - mdpi.com
Simple Summary Although NRF1 (nuclear factor erythroid 2-like 1; NFE2L1) and NRF2
(nuclear factor erythroid 2-like 2; NFE2L2) belong to the CNC (cap 'n'collar) transcription …
(nuclear factor erythroid 2-like 2; NFE2L2) belong to the CNC (cap 'n'collar) transcription …
[HTML][HTML] p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation
The ATPase p97 is a central component of the ubiquitin-proteasome degradation system.
p97 uses its ATPase activity and co-factors to extract ubiquitinated substrates from different …
p97 uses its ATPase activity and co-factors to extract ubiquitinated substrates from different …