The rapid proliferation of cancer cells combined with deficient vessels cause regions of
nutrient and O2 deprivation in solid tumors. Some cancer cells can adapt to these extreme …

Fluorescent probes have long been valuable tools in the study of biological systems. With
the ever-expanding range of known enzymatic biomarkers for disease, it has never been …

Reduced oxygen levels (hypoxia) is one of the most important factors influencing clinical
outcome after radiotherapy. This is primarily because hypoxic cells are resistant to radiation …

A kind of fluorescent/phosphorescent dual-emissive conjugated polyelectrolyte has been
prepared by introducing phosphorescent platinum (II) porphyrin (O2-sensitive) into a …

The observation of aerobic glycolysis by tumor cells in 1924 by Otto Warburg, and
subsequent innovation of imaging glucose uptake by tumors in patients with PET-CT, has …

Large tumours contain regions with very low intracellular O2 concentrations. Known as
hypoxia, this feature of tumours yields a highly reducing environment owing to the presence …

A novel long-wavelength fluorescence probe NBP has been developed for the detection of
nitroreductase (NTR) and hypoxia. NBP could be activated by NTR at 0.1 μM to release the …

We report a pair of fluorinated, redox-active copper complexes for potential use as 19F MRI
contrast agents for detecting cellular hypoxia. Trifluorinated Cu (II) ATSM-F3 displays the …

Hypoxia results from an imbalance between oxygen supply and consumption. It is a
common phenomenon in solid malignant tumors such as head and neck cancer. As hypoxic …

We report a fully reversible off–on fluorescence probe for hypoxia. The design employs QSY-
21 as a Förster resonance energy transfer (FRET) acceptor and cyanine dye Cy5 as a …