New attention to sexual dimorphism in normal mammalian physiology and disease has
uncovered a previously unappreciated breadth of mechanisms by which females and males …

Since their discovery by Steinman and Cohn in 1973, dendritic cells (DCs) have become
increasingly recognized for their crucial role as regulators of innate and adaptive immunity …

Human cytomegalovirus (HCMV) infections of healthy individuals are mostly unnoticed and
result in viral latency. However, HCMV can also cause devastating disease, eg, upon …

Circulating senescent CD8+ T (T8sen) cells are characterized by a lack of proliferative
capacities but retain cytotoxic activity and have been associated to resistance to …

Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …

Viruses manipulate the function of dendritic cells (DCs) to enhance their entry, spread,
survival and transmission. This review summarises recently published work identifying how …

Human cytomegalovirus (HCMV) is a ubiquitous double-stranded DNA virus belonging to
the β-subgroup of the herpesvirus family. After the initial infection, the virus establishes …

The immune system has evolved multipronged responses that are critical to effectively
defend the body from invading pathogens and to clear infection. However, the same …

The capacity of viruses to successfully infect the immunocompetent host to cause disease
argues in favor of virus-encoded functions that specifically target components of the immune …

We have assessed two approaches to sequencing complete human cytomegalovirus
(HCMV) genomes (236 kbp) in DNA extracted from infected cell cultures (strains 3157 …