The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …

The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …

As the primary cellular location for respiration and energy production, mitochondria serve in
a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria …

Expressed genes are scanned by translocating RNA polymerases, which sensitively detect
DNA damage and initiate transcription-coupled repair (TCR), a subpathway of nucleotide …

Eukaryotic transcription-coupled repair (TCR) is an important and well-conserved sub-
pathway of nucleotide excision repair that preferentially removes DNA lesions from the …

In the developing embryo and fetus, endogenous or xenobiotic-enhanced formation of
reactive oxygen species (ROS) like hydroxyl radicals may adversely alter development by …

DNA repair mechanisms are critical for maintaining the integrity of genomic DNA, and their
loss is associated with cancer predisposition syndromes. Studies in Saccharomyces …

Transcription-coupled nucleotide-excision repair (TC-NER) is a subpathway of NER that
efficiently removes the highly toxic RNA polymerase II blocking lesions in DNA. Defective TC …

In response to transcription-blocking DNA lesions such as those generated by UV
irradiation, cells activate a multipronged DNA damage response. This response …

DNA double-strand break (DSB) repair interferes with ongoing cellular processes, including
replication and transcription. Although the process of replication stalling upon collision of …