NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology
The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …
identified in the membrane of phagocytic cells. For many years, its only known role was in …
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
Many roads lead to CASM: Diverse stimuli of noncanonical autophagy share a unifying molecular mechanism
Autophagy is a fundamental catabolic process coordinated by a network of autophagy-
related (ATG) proteins. These ATG proteins also perform an important parallel role in …
related (ATG) proteins. These ATG proteins also perform an important parallel role in …
RETRACTED ARTICLE: Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins
J Martinez, RKS Malireddi, Q Lu, LD Cunha… - Nature cell …, 2015 - nature.com
Abstract LC3-associated phagocytosis (LAP) is a process wherein elements of autophagy
conjugate LC3 to phagosomal membranes. We characterize the molecular requirements for …
conjugate LC3 to phagosomal membranes. We characterize the molecular requirements for …
Autophagy in infection, inflammation and immunity
Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity.
Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it …
Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
PAMP s and DAMP s: Signal 0s that spur autophagy and immunity
Pathogen‐associated molecular pattern molecules (PAMP s) are derived from
microorganisms and recognized by pattern recognition receptor (PRR)‐bearing cells of the …
microorganisms and recognized by pattern recognition receptor (PRR)‐bearing cells of the …
Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice
S Tanaka, H Hikita, T Tatsumi, R Sakamori, Y Nozaki… - Hepatology, 2016 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. It
encompasses a spectrum ranging from simple steatosis to fatty liver with hepatocellular …
encompasses a spectrum ranging from simple steatosis to fatty liver with hepatocellular …
The clearance of dying cells: table for two
Phagocytic cells of the immune system must constantly survey for, recognize, and efficiently
clear the billions of cellular corpses that arise as a result of development, stress, infection, or …
clear the billions of cellular corpses that arise as a result of development, stress, infection, or …
Activation and targeting of ATG8 protein lipidation
S Martens, D Fracchiolla - Cell discovery, 2020 - nature.com
ATG8 family proteins are evolutionary conserved ubiquitin-like modifiers, which become
attached to the headgroup of the membrane lipid phosphatidylethanolamine in a process …
attached to the headgroup of the membrane lipid phosphatidylethanolamine in a process …