CRISPR-Cas9–based genetic screens are a powerful new tool in biology. By simply altering
the sequence of the single-guide RNA (sgRNA), one can reprogram Cas9 to target different …

Rift Valley fever virus (RVFV) is a zoonotic pathogen with pandemic potential. RVFV entry is
mediated by the viral glycoprotein (Gn), but host entry factors remain poorly defined. Our …

A murine cell line (BV-2) has been generated by infecting primary microglial cell cultures
with a-raf/v-myc oncogene carrying retrovirus (J2). BV-2 cells expressed nonspecific …

Septic shock caused by a diverse group of bacterial pathogens is a serious human disease.
Recognition of bacterial envelope constituents is one mechanism used by mammalian cells …

Murine cultured microglial cells were immortalized after infection with av‐raf/v‐myc
recombinant retro‐virus. This immortalized cell line (BV‐2) shares properties with body …

Developmental toxicity testing urgently requires the implementation of human-relevant new
approach methodologies (NAMs) that better recapitulate the peculiar nature of human …

To explore regulation of potentially lethal responses to bacterial lipopolysaccharide (LPS),
we used differential display under LPS-free conditions to compare macrophage cell lines …

The induction of cytokine synthesis by flagellin is mediated by a Toll-like receptor 5 (TLR5)
signaling pathway. Although flagellin activation of the IL-1R-associated kinase and induction …

Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is known to mediate
a wide variety of pharmacological and toxicological effects caused by polycyclic aromatic …

Secretory leukocyte protease inhibitor (SLPI) is a small but powerful member of the serine
protease inhibitor family, which includes proteins such as elafin and α1-antitrypsin. These …