The multi-factorial nature of clinical multidrug resistance in cancer
Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
MicroRNAs in central nervous system diseases: a prospective role in regulating blood-brain barrier integrity
Given the essential role of the blood-brain barrier (BBB) in the central nervous system
(CNS), cumulative investigations have been performed to elucidate how modulation of BBB …
(CNS), cumulative investigations have been performed to elucidate how modulation of BBB …
[HTML][HTML] Extracellular MicroRNA in liquid biopsy: applicability in cancer diagnosis and prevention
A Izzotti, S Carozzo, A Pulliero… - American journal of …, 2016 - ncbi.nlm.nih.gov
One of the goals of contemporary cancer research is the development of new markers that
facilitate earlier and non-invasive diagnosis. MicroRNAs are non-coding RNA molecules …
facilitate earlier and non-invasive diagnosis. MicroRNAs are non-coding RNA molecules …
Nanotechnological based miRNA intervention in the therapeutic management of neuroblastoma
Neuroblastoma (NB) is a widely diagnosed cancer in children, characterized by
amplification of the gene encoding the MYCN transcription factor, which is highly predictive …
amplification of the gene encoding the MYCN transcription factor, which is highly predictive …
MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways
Ovarian cancer is the most lethal gynecological malignancy due to the silent nature on its
early onset and the rapid acquisition of drug resistance. Histologically heterogeneous, it …
early onset and the rapid acquisition of drug resistance. Histologically heterogeneous, it …
Therapy resistance in neuroblastoma: Mechanisms and reversal strategies
X Zhou, X Wang, N Li, Y Guo, X Yang… - Frontiers in …, 2023 - frontiersin.org
Neuroblastoma is one of the most common pediatric solid tumors that threaten the health of
children, accounting for about 15% of childhood cancer-related mortality in the United …
children, accounting for about 15% of childhood cancer-related mortality in the United …
[HTML][HTML] microRNA-497 prevents pancreatic cancer stem cell gemcitabine resistance, migration, and invasion by directly targeting nuclear factor kappa B 1
Q Yu, Z Xiu, Y Jian, J Zhou, X Chen, X Chen… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Objectives: Cancer stem cells (CSCs) comprise a small population of cells in cancerous
tumors and play a critical role in tumor resistance to chemotherapy. miRNAs have been …
tumors and play a critical role in tumor resistance to chemotherapy. miRNAs have been …
Engineering pH‐Sensitive Stable Nanovesicles for Delivery of MicroRNA Therapeutics
A Boloix, N Feiner‐Gracia, M Köber, J Repetto… - Small, 2022 - Wiley Online Library
MicroRNAs (miRNAs) are small non‐coding endogenous RNAs, which are attracting a
growing interest as therapeutic molecules due to their central role in major diseases …
growing interest as therapeutic molecules due to their central role in major diseases …
miRNAs: micro-managers of anticancer combination therapies
JR van Beijnum, E Giovannetti, D Poel… - Angiogenesis, 2017 - Springer
Angiogenesis is one of the hallmarks of cancer progression and as such has been
considered a target of therapeutic interest. However, single targeted agents have not fully …
considered a target of therapeutic interest. However, single targeted agents have not fully …
Role of non-coding RNAs in neuroblastoma
AA Anoushirvani, A Jafarian Yazdi, S Amirabadi… - Cancer Gene …, 2023 - nature.com
Neuroblastoma is known as the most prevalent extracranial malignancy in childhood with a
neural crest origin. It has been widely accepted that non-coding RNAs (ncRNAs) play …
neural crest origin. It has been widely accepted that non-coding RNAs (ncRNAs) play …