Recent insight into the biological activities and SAR of quinolone derivatives as multifunctional scaffold
Quinolones are a type of bicyclic privileged building block with immense therapeutic
potential. They are known for their crucial role in modulating numerous diseases conditions …
potential. They are known for their crucial role in modulating numerous diseases conditions …
Investigation of antifungal properties of synthetic dimethyl-4-bromo-1-(substituted benzoyl) pyrrolo [1, 2-a] quinoline-2, 3-dicarboxylates analogues: Molecular docking …
V Uppar, S Chandrashekharappa, C Shivamallu, SP… - Molecules, 2021 - mdpi.com
Candida albicans, an opportunistic fungal pathogen, frequently colonizes immune-
compromised patients and causes mild to severe systemic reactions. Only few antifungal …
compromised patients and causes mild to severe systemic reactions. Only few antifungal …
Biological properties of pyrroloquinoline and pyrroloisoquinoline derivatives
P Králová, M Soural - European Journal of Medicinal Chemistry, 2024 - Elsevier
In this review, we summarize pyrroloquinoline and pyrroloisoquinoline derivatives (PQs and
PIQs) that act on a broad spectrum of biological targets and are used as bacteriostatic …
PIQs) that act on a broad spectrum of biological targets and are used as bacteriostatic …
Cytotoxicity and Antimycobacterial Properties of Pyrrolo[1,2-a]quinoline Derivatives: Molecular Target Identification and Molecular Docking Studies
KN Venugopala, V Uppar, S Chandrashekharappa… - Antibiotics, 2020 - mdpi.com
A series of ethyl 1-(substituted benzoyl)-5-methylpyrrolo [1, 2-a] quinoline-3-carboxylates 4a–
f and dimethyl 1-(substituted benzoyl)-5-methylpyrrolo [1, 2-a] quinoline-2, 3-dicarboxylates …
f and dimethyl 1-(substituted benzoyl)-5-methylpyrrolo [1, 2-a] quinoline-2, 3-dicarboxylates …
Synthesis of novel pyrrolo [1, 2-a] quinoline derivatives as a new class of anti-inflammatory and antimicrobial agents: An approach to single crystal X-ray structure …
We report the synthesis and characterisation of pyrrolo [1, 2-a] quinoline derivatives 3a-c.
The synthesised compounds were characterised by FTIR, 1 H NMR, 13 C NMR, and mass …
The synthesised compounds were characterised by FTIR, 1 H NMR, 13 C NMR, and mass …
Two distinct protocols for the synthesis of unsymmetrical 3, 4-disubstituted maleimides based on transition-metal catalysts
F Bandehali-Naeini, Z Tanbakouchian… - Organic & …, 2024 - pubs.rsc.org
Two tandem catalytic systems are described for the synthesis of novel 3, 4-disubstituted
maleimides using the same Ugi adducts as starting materials. 4-Aryl-3-pyrrolyl-and 4-aryl-3 …
maleimides using the same Ugi adducts as starting materials. 4-Aryl-3-pyrrolyl-and 4-aryl-3 …
One-pot construction of novel trifluoromethyl dihydro-imidazo [1, 2-a] pyridine: A greener approach
A one-pot three-component method for the synthesis of 3-substituted 2-trifluoromethyl-2, 3-
dihydroimidazo [1, 2-a] pyridin-3-yl analogues from 2-aminopyridine, substituted phenacyl …
dihydroimidazo [1, 2-a] pyridin-3-yl analogues from 2-aminopyridine, substituted phenacyl …
Synthesis, characterization and larvicidal studies of ethyl 3-benzoyl-7-(piperidin-1-yl)indolizine-1-carboxylate analogues against Anopheles arabiensis and …
SU Shende, NA Al-Shar'i, SM Saini… - Journal of …, 2024 - Taylor & Francis
According to WHO, in 2021, there was an estimation of 247 million malaria cases from 84
malaria-endemic countries. Globally an estimated count of 2 billion malaria cases and 11.7 …
malaria-endemic countries. Globally an estimated count of 2 billion malaria cases and 11.7 …
Design, synthesis and in vitro antitubercular evaluation of novel 7-methoxy pyrrolo [1, 2-a] quinoline analogues as CYP 121 inhibitors
K Shivaprasad, S Kidwai, S Gopavaram… - Journal of Molecular …, 2023 - Elsevier
A novel series of pyrrolo [1, 2-a] quinoline analogues (4a-n) was designed via a heterocyclic
fusion approach for their antitubercular evaluation. The targeted compounds were …
fusion approach for their antitubercular evaluation. The targeted compounds were …
Bio-computational modeling, POM analysis and molecular dynamic simulation for novel synthetic quinolone and benzo[d][1,3]oxazine candidates as antimicrobial …
DA Elsayed, ME Abdu, MA Marzouk, EM Mahmoud… - Scientific reports, 2024 - nature.com
The current study offers a metal-free, direct, and successful synthesis technique for a new
series of quinolinone and benzo [d][1, 3] oxazine, along with an assessment of their …
series of quinolinone and benzo [d][1, 3] oxazine, along with an assessment of their …