The balance of Th17 versus Treg cells in autoimmunity
GR Lee - International journal of molecular sciences, 2018 - mdpi.com
T helper type 17 (Th17) cells and pTreg cells, which share a common precursor cell (the
naïve CD4 T cell), require a common tumor growth factor (TGF)-β signal for initial …
naïve CD4 T cell), require a common tumor growth factor (TGF)-β signal for initial …
CD28 costimulation: from mechanism to therapy
JH Esensten, YA Helou, G Chopra, A Weiss… - Immunity, 2016 - cell.com
Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell
receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure …
receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure …
Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
Recent studies have identified a unique cancer-associated fibroblast (CAF) population
termed antigen-presenting CAFs (apCAFs), characterized by the expression of major …
termed antigen-presenting CAFs (apCAFs), characterized by the expression of major …
Molecular biology of atherosclerosis
PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
Induction of tolerance and immunity by dendritic cells: mechanisms and clinical applications
J Fucikova, L Palova-Jelinkova, J Bartunkova… - Frontiers in …, 2019 - frontiersin.org
Dendritic cells (DCs) are key regulators of immune responses that operate at the interface
between innate and adaptive immunity, and defects in DC functions contribute to the …
between innate and adaptive immunity, and defects in DC functions contribute to the …
Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy
We study a patient with the human papilloma virus (HPV)-2-driven" tree-man" phenotype
and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2 …
and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2 …
Generation and function of induced regulatory T cells
EG Schmitt, CB Williams - Frontiers in immunology, 2013 - frontiersin.org
CD4+ CD25+ Foxp3+ regulatory T (Treg) cells are essential to the balance between pro-and
anti-inflammatory responses. There are two major subsets of Treg cells,“natural” Treg …
anti-inflammatory responses. There are two major subsets of Treg cells,“natural” Treg …
Rebalancing immune homeostasis to treat autoimmune diseases
During homeostasis, interactions between tolerogenic dendritic cells (DCs), self-reactive T
cells, and T regulatory cells (Tregs) contribute to maintaining mammalian immune tolerance …
cells, and T regulatory cells (Tregs) contribute to maintaining mammalian immune tolerance …
Role of IL-6 in dendritic cell functions
YD Xu, M Cheng, PP Shang… - Journal of Leukocyte …, 2022 - academic.oup.com
Dendritic cells (DCs) are efficient antigen-presenting cells that serve as a link between the
innate and adaptive immune systems. These cells are broadly involved in cellular and …
innate and adaptive immune systems. These cells are broadly involved in cellular and …
Mechanisms of human FoxP3+ Treg cell development and function in health and disease
M Attias, T Al-Aubodah… - Clinical & experimental …, 2019 - academic.oup.com
Regulatory T (Treg) cells represent an essential component of peripheral tolerance. Given
their potently immunosuppressive functions that is orchestrated by the lineage-defining …
their potently immunosuppressive functions that is orchestrated by the lineage-defining …