What makes the sinoatrial node tick? A question not for the faint of heart
L Donald, EG Lakatta - Philosophical Transactions of the …, 2023 - royalsocietypublishing.org
Even before the sinoatrial node (SAN) was discovered, cardiovascular science was
engaged in an active investigation of when and why the heart would beat. After the …
engaged in an active investigation of when and why the heart would beat. After the …
Paradigm shift: new concepts for HCN4 function in cardiac pacemaking
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are the molecular
correlate of the If current and are critically involved in controlling neuronal excitability and …
correlate of the If current and are critically involved in controlling neuronal excitability and …
L-Type Cav1.3 Calcium Channels Are Required for Beta-Adrenergic Triggered Automaticity in Dormant Mouse Sinoatrial Pacemaker Cells
J Louradour, O Bortolotti, E Torre, I Bidaud, N Lamb… - Cells, 2022 - mdpi.com
Background: Sinoatrial node cells (SANC) automaticity is generated by functional
association between the activity of plasmalemmal ion channels and local diastolic …
association between the activity of plasmalemmal ion channels and local diastolic …
Genetics of sinoatrial node function and heart rate disorders
LE van der Maarel, AV Postma… - Disease models & …, 2023 - journals.biologists.com
The sinoatrial node (SAN) is the primary pacemaker of the mammalian heart, initiating its
electrical activation and ensuring that the heart's functional cardiac output meets …
electrical activation and ensuring that the heart's functional cardiac output meets …
Functional heterogeneity of cell populations increases robustness of pacemaker function in a numerical model of the sinoatrial node tissue
AV Maltsev, MD Stern, EG Lakatta… - Frontiers in physiology, 2022 - frontiersin.org
Each heartbeat is initiated by specialized pacemaker cells operating within the sinoatrial
node (SAN). While individual cells within SAN tissue exhibit substantial heterogeneity of …
node (SAN). While individual cells within SAN tissue exhibit substantial heterogeneity of …
[HTML][HTML] Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains
Sinoatrial node (SAN) cells are the heart's primary pacemaker. Their activity is tightly
regulated by β-adrenergic receptor (β-AR) signaling. Adenylyl cyclase (AC) is a key enzyme …
regulated by β-adrenergic receptor (β-AR) signaling. Adenylyl cyclase (AC) is a key enzyme …
Remembering the canonical discoverers of the core components of the mammalian cardiac conduction system: Keith and Flack, Aschoff and Tawara, His, and Purkinje
I Cavero, H Holzgrefe - Advances in Physiology Education, 2022 - journals.physiology.org
The mammalian cardiac conduction system (CCS) is a multifaceted continuum of electrically
distinct, interconnected constructs within the myocardial mass. The key components are the …
distinct, interconnected constructs within the myocardial mass. The key components are the …
The paradigm shift: heartbeat initiation without “the pacemaker cell”
VA Maltsev, MD Stern - Frontiers in Physiology, 2022 - frontiersin.org
The current dogma about the heartbeat origin is based on “the pacemaker cell,” a
specialized cell residing in the sinoatrial node (SAN) that exhibits spontaneous diastolic …
specialized cell residing in the sinoatrial node (SAN) that exhibits spontaneous diastolic …
β-Adrenergic stimulation synchronizes a broad spectrum of action potential firing rates of cardiac pacemaker cells toward a higher population average
MS Kim, O Monfredi, LA Maltseva, EG Lakatta… - Cells, 2021 - mdpi.com
The heartbeat is initiated by pacemaker cells residing in the sinoatrial node (SAN). SAN
cells generate spontaneous action potentials (APs), ie, normal automaticity. The sympathetic …
cells generate spontaneous action potentials (APs), ie, normal automaticity. The sympathetic …
Activation of IP3R in atrial cardiomyocytes leads to generation of cytosolic cAMP
EC Akerman, MJ Read, SJ Bose… - American Journal …, 2024 - journals.physiology.org
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Excessive
stimulation of the inositol (1, 4, 5)-trisphosphate (IP3) signaling pathway has been linked to …
stimulation of the inositol (1, 4, 5)-trisphosphate (IP3) signaling pathway has been linked to …