Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease
Ageing and inflammation strongly drive the risk of cardiovascular disease. Work over the
past decade has uncovered a common condition characterized by the positive selection of …
past decade has uncovered a common condition characterized by the positive selection of …
Genetics of MDS
S Ogawa - Blood, The Journal of the American Society of …, 2019 - ashpublications.org
Our knowledge about the genetics of myelodysplastic syndromes (MDS) and related
myeloid disorders has been dramatically improved during the past decade, in which …
myeloid disorders has been dramatically improved during the past decade, in which …
Genetic basis and molecular pathophysiology of classical myeloproliferative neoplasms
W Vainchenker, R Kralovics - … Journal of the American Society of …, 2017 - ashpublications.org
The genetic landscape of classical myeloproliferative neoplasm (MPN) is in large part
elucidated. The MPN-restricted driver mutations, including those in JAK2, calreticulin …
elucidated. The MPN-restricted driver mutations, including those in JAK2, calreticulin …
Age-related mutations associated with clonal hematopoietic expansion and malignancies
Several genetic alterations characteristic of leukemia and lymphoma have been detected in
the blood of individuals without apparent hematological malignancies. The Cancer Genome …
the blood of individuals without apparent hematological malignancies. The Cancer Genome …
Obesity-induced inflammation exacerbates clonal hematopoiesis
SK Pasupuleti, B Ramdas, SS Burns… - The Journal of …, 2023 - Am Soc Clin Investig
Characterized by the accumulation of somatic mutations in blood cell lineages, clonal
hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the …
hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the …
Somatic mutations and clonal hematopoiesis in aplastic anemia
T Yoshizato, B Dumitriu, K Hosokawa… - … England Journal of …, 2015 - Mass Medical Soc
Background In patients with acquired aplastic anemia, destruction of hematopoietic cells by
the immune system leads to pancytopenia. Patients have a response to immunosuppressive …
the immune system leads to pancytopenia. Patients have a response to immunosuppressive …
The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes
DA Sallman, A List - Blood, The Journal of the American Society …, 2019 - ashpublications.org
In cancer biology, tumor-promoting inflammation and an inflammatory microenvironment
play a vital role in disease pathogenesis. In the past decade, aberrant innate immune …
play a vital role in disease pathogenesis. In the past decade, aberrant innate immune …
The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype
AA Basiorka, KL McGraw, EA Eksioglu… - Blood, The Journal …, 2016 - ashpublications.org
Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of
cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDSs is …
cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDSs is …
Clonal hematopoiesis: mechanisms driving dominance of stem cell clones
GA Challen, MA Goodell - Blood, The Journal of the American …, 2020 - ashpublications.org
The discovery of clonal hematopoiesis (CH) in older individuals has changed the way
hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem …
hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem …
Loss of BAP1 function leads to EZH2-dependent transformation
The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase
complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub). However …
complex that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub). However …