Weight gain and integrase inhibitors

AR Eckard, GA McComsey - Current opinion in infectious diseases, 2020 - journals.lww.com
Although INSTI-based regimens are highly efficacious for viral suppression, they appear to
cause more weight gain and treatment emergent obesity than non-INSTI-based regimens …

HIV-1 integrase inhibitors: a comparative review of efficacy and safety

KK Scarsi, JP Havens, AT Podany, SN Avedissian… - Drugs, 2020 - Springer
The newest class of antiretrovirals for all persons living with HIV are the integrase strand
transfer inhibitors (INSTIs). Since 2007, five INSTIs have been introduced: raltegravir …

Weight gain following initiation of antiretroviral therapy: risk factors in randomized comparative clinical trials

PE Sax, KM Erlandson, JE Lake… - Clinical Infectious …, 2020 - academic.oup.com
Background Initiation of antiretroviral therapy (ART) often leads to weight gain. While some
of this weight gain may be an appropriate return-to-health effect, excessive increases in …

Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2020 recommendations of the International Antiviral Society–USA Panel

MS Saag, RT Gandhi, JF Hoy, RJ Landovitz… - Jama, 2020 - jamanetwork.com
Importance Data on the use of antiretroviral drugs, including new drugs and formulations, for
the treatment and prevention of HIV infection continue to guide optimal practices. Objective …

Weight gain among treatment‐naïve persons with HIV starting integrase inhibitors compared to non‐nucleoside reverse transcriptase inhibitors or protease inhibitors …

K Bourgi, CA Jenkins, PF Rebeiro… - Journal of the …, 2020 - Wiley Online Library
Introduction Weight gain following antiretroviral therapy (ART) initiation is common,
potentially predisposing some persons with HIV (PWH) to cardio‐metabolic disease. We …

Weight gain before and after switch from TDF to TAF in a US cohort study

PWG Mallon, L Brunet, RK Hsu, JS Fusco… - African Journal of …, 2021 - journals.lww.com
Introduction: Although weight gain has been reported with the use of integrase strand
transfer inhibitors (InSTI), concurrent use of tenofovir alafenamide (TAF) has been implicated …

Obesity and weight gain in persons with HIV

SS Bailin, CL Gabriel, CN Wanjalla… - Current HIV/AIDS Reports, 2020 - Springer
Abstract Purpose of Review The proportion of overweight and obese persons with HIV
(PWH) has increased since the introduction of antiretroviral therapy (ART). We aim to …

Metabolic complications affecting adipose tissue, lipid and glucose metabolism associated with HIV antiretroviral treatment

C Lagathu, V Béréziat, J Gorwood… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Efficient antiretroviral-treatment (ART) generally allows control of HIV infection.
However, persons-living-with-HIV (PLWH), when aging, present a high prevalence of …

Weight gain associated with integrase stand transfer inhibitor use in women

AM Kerchberger, AN Sheth, CD Angert… - Clinical infectious …, 2020 - academic.oup.com
Background Integrase strand-transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is
recommended for human immunodeficiency virus (HIV) management. Although studies …

Risk of incident diabetes mellitus, weight gain, and their relationships with integrase inhibitor–based initial antiretroviral therapy among persons with human …

PF Rebeiro, CA Jenkins, A Bian, JE Lake… - Clinical Infectious …, 2021 - academic.oup.com
Background Integrase strand transfer inhibitor (INSTI)–based combination antiretroviral
therapy (cART) is associated with greater weight gain among persons with human …