Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

Alzheimer's disease (AD) represents the most common form of dementia among older age
subjects, and despite decades of studies, the underlying mechanisms remain unresolved …

The older Finnish Twin Cohort (FTC) was established in 1974. The baseline survey was in
1975, with two follow-up health surveys in 1981 and 1990. The fourth wave of assessments …

The importance of macrostructural white matter changes, including white matter lesions and
atrophy, in intact brain functioning is increasingly being recognized. Diffusion tensor imaging …

Age is the strongest risk factor for sporadic Alzheimer disease (AD), yet the effects of age on
rates of clinical decline and brain atrophy in AD have been largely unexplored. Here, we …

Kognitiivinen ikääntyminen kuuluu läpi elämän tapahtuviin muutoksiin muistissa ja muissa
tiedon käsittelyyn liittyvissä toiminnoissa. Monet kognition osaalueet alkavat heiketä jo …

Background Epidemiological studies commonly include too few of the oldest old to provide
accurate prevalence rates of dementia in older age groups. Estimates of the number of those …

Background Results conflict concerning the relevance of APOE alleles on the development
of dementia with Lewy bodies (DLB), though they are well established in connection with …

Objective: It has been hypothesized that individuals without dementia with Alzheimer
disease (AD) neuropathology may be in the preclinical stages of dementia and could be …

The oldest-old are the fastest growing segment of the Western population. Over half of the
oldest-old will have dementia, but the etiology is yet unknown. Age is the only risk factor …