Heat shock protein 90 (HSP90) is a vital chaperone protein, regulating signaling pathways
and correcting misfolded proteins in cancer cells by interacting with oncogenic client …

Molecular chaperones HSP90 and HSP70 are essential regulators of the folding and
activation of a disparate ensemble of client proteins. They function through ATP hydrolysis …

Heat shock proteins (Hsps) are molecular chaperones that also play important roles in the
activation of the heat shock response (HSR). The HSR is an evolutionary conserved and …

Herein we examine the determinants of the allosteric inhibition of the mitochondrial
chaperone TRAP1 by a small molecule ligand. The knowledge generated is harnessed into …

Abstract Parkinson's disease (PD), the second most common neurodegenerative disorder, is
characterized by loss of dopaminergic neurons in the substantia nigra, as well as the …

Abstract KU-32 (2) and KU-596 (3), are first and second generation cytoprotective
novologues that are derivatives of novobiocin (1), a heat shock protein 90 (Hsp90) C …

A Pd-catalyzed aerobic approach to access C4-aryl benzoxazoles by tandem C–H ortho-
arylation and acid-mediated annulation of 2-amidophenol has been presented. The …

The Blagg research lab is an interdisciplinary medicinal chemistry and chemical biology
team focused on the rational design of new molecules and advancing putative therapeutic …

From the roots of Campylotropis hirtella (Franch.) Schindl., many natural dihydroflavonol
compounds have been extracted, and they possess a structurally novel feature of chiral …

Rakava obolenja ostajajo eden od vodilnih vzrokov umrljivosti po vsem svetu. Čeprav je
zdravljenje v zadnjih desetletjih precej napredovalo, ostajata neselektivnost učinkovin in …