The interaction between ferroptosis and inflammatory signaling pathways

Y Chen, ZM Fang, X Yi, X Wei, DS Jiang - Cell death & disease, 2023 - nature.com
Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation.
Inflammation is one common and effective physiological event that protects against various …

Role of vascular smooth muscle cell plasticity and interactions in vessel wall inflammation

V Sorokin, K Vickneson, T Kofidis, CC Woo… - Frontiers in …, 2020 - frontiersin.org
The pathobiology of atherosclerotic disease requires further elucidation to discover new
approaches to address its high morbidity and mortality. To date, over 17 million …

Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity

P Li, M Jiang, K Li, H Li, Y Zhou, X Xiao, Y Xu… - Nature …, 2021 - nature.com
The linkage between neutrophil death and the development of autoimmunity has not been
thoroughly explored. Here, we show that neutrophils from either lupus-prone mice or …

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

C Silvestre-Roig, Q Braster, K Wichapong, EY Lee… - Nature, 2019 - nature.com
The perpetuation of inflammation is an important pathophysiological contributor to the global
medical burden. Chronic inflammation is promoted by non-programmed cell death,; …

Programmed cell death in spinal cord injury pathogenesis and therapy

Z Shi, S Yuan, L Shi, J Li, G Ning, X Kong… - Cell …, 2021 - Wiley Online Library
Spinal cord injury (SCI) always leads to functional deterioration due to a series of processes
including cell death. In recent years, programmed cell death (PCD) is considered to be a …

Excessive apoptosis in ulcerative colitis: crosstalk between apoptosis, ROS, ER stress, and intestinal homeostasis

Y Wan, L Yang, S Jiang, D Qian… - Inflammatory bowel …, 2022 - academic.oup.com
Ulcerative colitis (UC), an etiologically complicated and relapsing gastrointestinal disease, is
characterized by the damage of mucosal epithelium and destruction of the intestinal …

Living on the edge: efferocytosis at the interface of homeostasis and pathology

S Morioka, C Maueröder, KS Ravichandran - Immunity, 2019 - cell.com
Nearly every tissue in the body undergoes routine turnover of cells as part of normal healthy
living. The majority of these cells undergoing turnover die via apoptosis, and then are rapidly …

Platelet and megakaryocyte roles in innate and adaptive immunity

M Koupenova, AC Livada, CN Morrell - Circulation research, 2022 - Am Heart Assoc
Classically, platelets have been described as the cellular blood component that mediates
hemostasis and thrombosis. This important platelet function has received significant …

Lytic cell death in metabolic liver disease

J Gautheron, GJ Gores, CMP Rodrigues - Journal of hepatology, 2020 - Elsevier
Regulated cell death is intrinsically associated with inflammatory liver disease and is pivotal
in governing outcomes of metabolic liver disease. Different types of cell death may coexist …

Guidelines for regulated cell death assays: a systematic summary, a categorical comparison, a prospective

X Hu, Z Li, R Lin, J Shan, Q Yu, R Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Over the past few years, the field of regulated cell death continues to expand and novel
mechanisms that orchestrate multiple regulated cell death pathways are being unveiled …