Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

Wnt signaling is one of the important pathways to play a major role in various biological
processes, such as embryonic stem-cell development, tissue regeneration, cell …

Oxoguanine, a common mutagenic DNA lesion, generates G: C> T: A transversions via
mispairing with adenine during DNA replication. When operating normally, the MUTYH DNA …

The crosstalk between ferroptosis and cancer metastasis remains unclear. Here, we identify
AMER1 as a key regulator of ferroptosis. AMER1 loss causes resistance to ferroptosis in …

Background: Somatic copy number aberrations (CNAs) are common acquired changes in
cancer cells having an important role in the progression of colon cancer (colorectal cancer …

With the advances in high-throughput technologies, millions of somatic mutations have been
reported in the past decade. Identifying driver genes with oncogenic mutations from these …

The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of cytoplasmic
adaptor proteins regulate the signal transduction pathways of a variety of receptors …

Simple Summary Wnt has diverse regulatory roles at multiple cellular levels and numerous
targeting points, and aberrant Wnt signaling has crucial roles in carcinogenesis, metastasis …

Right-sided colon cancer (RCC) has worse prognosis compared to left-sided colon cancer
(LCC) and rectal cancer. The reason for this difference in outcomes is not well understood …

Metastatic colorectal cancer (CRC) is a common cause of cancer-related mortality, of which
peritoneal metastases (PMs) have the worse outcome. Metastasis-specific markers may help …