Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic
syndrome and the incidence of which is rising rapidly due to the increasing epidemic of …

Background Recent cohort studies show that salt intake below 6 g is associated with
increased mortality. These findings have not changed public recommendations to lower salt …

Since 1985, the thiazolidinedione pioglitazone has been widely used as an insulin
sensitizer drug for type 2 diabetes mellitus (T2DM). Although fluid retention was early …

Background The question of whether reduced sodium intake is effective as a health
prophylaxis initiative is unsolved. The purpose was to estimate the effects of low-sodium vs …

Although neurohumoral antagonism has successfully reduced heart failure morbidity and
mortality, the residual disability and death rate remains unacceptably high. Though …

Chronic heart failure (HF) and diabetes mellitus (DM) commonly coexist. Each condition
increases the likelihood of developing the other, and when they occur together in the same …

Introduction: Thiazolidinediones (TZDs) initially showed great promise as unique receptor-
mediated oral therapy for type 2 diabetes, but a host of serious side effects, primarily …

Because of their wide range of actions on glucose homeostasis, lipid metabolism and
vascular inflammation, peroxisome proliferator-activated receptors (PPARs) are promising …

The peroxisome proliferator-activated receptor subtype γ (PPARγ) ligands, namely the
synthetic insulin-sensitizing thiazolidinedione (TZD) compounds, have demonstrated great …

Background—Pulmonary arterial hypertension (PAH) is characterized, in part, by decreased
endothelial nitric oxide (NO·) production and elevated levels of endothelin-1. Endothelin-1 is …