A comprehensive overview on stress neurobiology: basic concepts and clinical implications

LD Godoy, MT Rossignoli, P Delfino-Pereira… - Frontiers in behavioral …, 2018 - frontiersin.org
Stress is recognized as an important issue in basic and clinical neuroscience research,
based upon the founding historical studies by Walter Canon and Hans Selye in the past …

The association between loneliness, social isolation and inflammation: A systematic review and meta-analysis

KJ Smith, S Gavey, NE RIddell, P Kontari… - … & Biobehavioral Reviews, 2020 - Elsevier
The review synthesised evidence examining the association between a. loneliness with
inflammation and b. social isolation with inflammation in adults aged 16 or older from the …

Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

M Gacias, S Gaspari, PMG Santos, S Tamburini… - elife, 2016 - elifesciences.org
Gene-environment interactions impact the development of neuropsychiatric disorders, but
the relative contributions are unclear. Here, we identify gut microbiota as sufficient to induce …

IL-6, IL-18, sIL-2R, and TNFα proinflammatory markers in depression and schizophrenia patients who are free of overt inflammation

HK Al-Hakeim, DA Al-Rammahi, AH Al-Dujaili - Journal of affective …, 2015 - Elsevier
Major depressive disorder (MDD) and schizophrenia are associated with inflammatory
processes. Studies have shown that these disorders exhibit increase in the level of one or …

Loneliness: an immunometabolic syndrome

H Pourriyahi, N Yazdanpanah, A Saghazadeh… - International journal of …, 2021 - mdpi.com
Loneliness has been defined as an agonizing encounter, experienced when the need for
human intimacy is not met adequately, or when a person's social network does not match …

Stress-induced disturbances along the gut microbiota-immune-brain axis and implications for mental health: Does sex matter?

MC Audet - Frontiers in neuroendocrinology, 2019 - Elsevier
Women are roughly twice as likely as men to suffer from stress-related disorders, especially
major depression and generalized anxiety. Accumulating evidence suggest that microbes …

Resilience: safety in the aftermath of traumatic stressor experiences

K Matheson, A Asokumar, H Anisman - Frontiers in behavioral …, 2020 - frontiersin.org
The relationship between adverse experiences and the emergence of pathology has often
focused on characteristics of the stressor or of the individual (stressor appraisals, coping …

Interplay between social isolation and loneliness and chronic systemic inflammation during the COVID-19 pandemic in Japan: Results from U-CORONA study

Y Koyama, N Nawa, Y Yamaoka, H Nishimura… - Brain, Behavior, and …, 2021 - Elsevier
In the face of the global coronavirus disease 2019 (COVID-19) pandemic, billions of people
were forced to stay at home due to the implementation of social distancing and lockdown …

[HTML][HTML] Focus: microbiome: integrative therapies in anxiety treatment with special emphasis on the gut microbiome

SL Schnorr, HA Bachner - The Yale journal of biology and …, 2016 - ncbi.nlm.nih.gov
Over the past decade, research has shown that diet and gut health affects symptoms
expressed in stress related disorders, depression, and anxiety through changes in the gut …

Possible role of the NLRP3 inflammasome and the gut–brain axis in multiple sclerosis‐related depression

K Maciak, A Dziedzic, J Saluk - The FASEB Journal, 2023 - Wiley Online Library
Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous
system that results from complex interactions between genetic and environmental …